TY - JOUR
T1 - Pancreatic Cancer Database
T2 - An integrative resource for pancreatic cancer
AU - Thomas, Joji Kurian
AU - Kim, Min Sik
AU - Balakrishnan, Lavanya
AU - Nanjappa, Vishalakshi
AU - Raju, Rajesh
AU - Marimuthu, Arivusudar
AU - Radhakrishnan, Aneesha
AU - Muthusamy, Babylakshmi
AU - Khan, Aafaque Ahmad
AU - Sakamuri, Sruthi
AU - Tankala, Shantal Gupta
AU - Singal, Mukul
AU - Nair, Bipin
AU - Sirdeshmukh, Ravi
AU - Chatterjee, Aditi
AU - Keshava Prasad, T. S.
AU - Maitra, Anirban
AU - Gowda, Harsha
AU - Hruban, Ralph H.
AU - Pandey, Akhilesh
N1 - Funding Information:
Pancreatic Cancer Database was funded by the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins University School of Medicine, Baltimore, MD USA.
Funding Information:
We thank Department of Biotechnology, Government of India for Research Support to Institute of Bioinformatics. Aneesha Radhakrishnan is a recipient of Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India. We acknowledge Praveen Kumar, Renu Goel and Sandhya Rani, Institute of Bioinformatics, Bangalore, India for their curation support and database development. We also thank Adwait Sodani, Aniruddha Sahu, Ankit Chawla, Ankit Kumar, Mahashweta Dash, and Satish Kumar from Armed Forces Medical College (AFMC), Pune, India, for critical reading of the manuscript.
PY - 2014/8
Y1 - 2014/8
N2 - Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.
AB - Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.
KW - Biomarker
KW - Body fluids
KW - Chronic pancreatitis
KW - Secreted
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U2 - 10.4161/cbt.29188
DO - 10.4161/cbt.29188
M3 - Article
C2 - 24839966
AN - SCOPUS:84905500620
SN - 1538-4047
VL - 15
SP - 963
EP - 967
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
IS - 8
ER -