Pancreatic Cancer Database: An integrative resource for pancreatic cancer

Joji Kurian Thomas, Min Sik Kim, Lavanya Balakrishnan, Vishalakshi Nanjappa, Rajesh Raju, Arivusudar Marimuthu, Aneesha Radhakrishnan, Babylakshmi Muthusamy, Aafaque Ahmad Khan, Sruthi Sakamuri, Shantal Gupta Tankala, Mukul Singal, Bipin Nair, Ravi Sirdeshmukh, Aditi Chatterjee, T. S. Keshava Prasad, Anirban Maitra, Harsha Gowda, Ralph H. Hruban, Akhilesh Pandey

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database (http://www.pancreaticcancerdatabase.org), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.

Original languageEnglish (US)
Pages (from-to)963-967
Number of pages5
JournalCancer Biology and Therapy
Volume15
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Biomarker
  • Body fluids
  • Chronic pancreatitis
  • Secreted

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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  • Cite this

    Thomas, J. K., Kim, M. S., Balakrishnan, L., Nanjappa, V., Raju, R., Marimuthu, A., Radhakrishnan, A., Muthusamy, B., Khan, A. A., Sakamuri, S., Tankala, S. G., Singal, M., Nair, B., Sirdeshmukh, R., Chatterjee, A., Keshava Prasad, T. S., Maitra, A., Gowda, H., Hruban, R. H., & Pandey, A. (2014). Pancreatic Cancer Database: An integrative resource for pancreatic cancer. Cancer Biology and Therapy, 15(8), 963-967. https://doi.org/10.4161/cbt.29188