Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report

Mark Steven Miller, Peter Allen, Teresa A. Brentnall, Michael Goggins, Ralph H. Hruban, Gloria M. Petersen, Chinthalapally V. Rao, David C. Whitcomb, Randall E. Brand, Suresh T. Chari, Alison P. Klein, David M. Lubman, Andrew D. Rhim, Diane M. Simeone, Brian M. Wolpin, Asad Umar, Sudhir Srivastava, Vernon E. Steele, Jo Ann S. Rinaudo

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 10%. The Division of Cancer Prevention of the National Cancer Institute sponsored the Pancreatic Cancer Chemoprevention Translational Workshop on September 10 to 11, 2015. The goal of the workshop was to obtain information regarding the current state of the science and future scientific areas that should be prioritized for pancreatic cancer prevention research, including early detection and intervention for high-risk precancerous lesions. The workshop addressed the molecular/genetic landscape of pancreatic cancer and precursor lesions, high-risk populations and criteria to identify a high-risk population for potential chemoprevention trials, identification of chemopreventative/immunopreventative agents, and use of potential biomarkers and imaging for assessing short-term efficacy of a preventative agent. The field of chemoprevention for pancreatic cancer is emerging, and this workshop was organized to begin to address these important issues and promote multi-institutional efforts in this area. The meeting participants recommended the development of an National Cancer Institute working group to coordinate efforts, provide a framework, and identify opportunities for chemoprevention of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1080-1091
Number of pages12
JournalPancreas
Volume45
Issue number8
DOIs
StatePublished - Sep 1 2016

Keywords

  • biomarkers
  • chemoprevention
  • clinical trials
  • early detection
  • high-risk patient cohorts
  • pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Miller, M. S., Allen, P., Brentnall, T. A., Goggins, M., Hruban, R. H., Petersen, G. M., Rao, C. V., Whitcomb, D. C., Brand, R. E., Chari, S. T., Klein, A. P., Lubman, D. M., Rhim, A. D., Simeone, D. M., Wolpin, B. M., Umar, A., Srivastava, S., Steele, V. E., & Rinaudo, J. A. S. (2016). Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report. Pancreas, 45(8), 1080-1091. https://doi.org/10.1097/MPA.0000000000000705