Pancreas regeneration after resection: Does it occur in humans?

Gregory G. Tsiotos, M. Kevin Barry, C. Daniel Johnson, Michael G. Sarr

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although pancreatic regeneration after partial resection or pancreatic injury (restitutio ad integrum) has been demonstrated in animal models, whether regeneration occurs in the human pancreas is unknown. Our aim was to determine whether the human pancreas regenerates after subtotal resection We reviewed pre- and postoperative computerized tomograms (CTs) of 21 patients after proximal pancreatectomy (5060% resection) for malignancy with no recurrent disease during follow-up of pancreatic parenchymal abnormalities. Three fixed anatomic measurements (pancreatic body width, tail width, and length) were compared with the same region 10 and 21 months after surgery. Data are expressed as mean ± SEM. Pancreatic measurements before and 10 months after resection did not differ for body width (2.0 ± 0.1 cm vs. 1.8 ± 0.1 cm), tail width (2.2 ± 0.2 cm vs. 1.8 ± 0.2 cm) or length (8.2 ± 0.3 vs. 7.4 ± 0.4 cm) (p ≥ 0.1 each). At 21 months after resection, measurements were less for body width and tall width (2.2 ± 0.2 cm vs. 1.5 ± 0.2 cm and 2.2 ± 0.1 cm vs. 1.5 ± 0.2 cm, respectively; p = 0.01) and unchanged for length (8.1 ± 0.4 cm vs. 81 ± 0.4 cm; p = 0.9). We conclude that the human pancreas does not regenerate after partial anatomic (50%) resection.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalPancreas
Volume19
Issue number3
StatePublished - Oct 1999

Fingerprint

Regeneration
Pancreas
Tail
Pancreatectomy
Animal Models
Wounds and Injuries
Neoplasms

Keywords

  • Pancreas
  • Regeneration

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology

Cite this

Tsiotos, G. G., Barry, M. K., Johnson, C. D., & Sarr, M. G. (1999). Pancreas regeneration after resection: Does it occur in humans? Pancreas, 19(3), 310-313.

Pancreas regeneration after resection : Does it occur in humans? / Tsiotos, Gregory G.; Barry, M. Kevin; Johnson, C. Daniel; Sarr, Michael G.

In: Pancreas, Vol. 19, No. 3, 10.1999, p. 310-313.

Research output: Contribution to journalArticle

Tsiotos, GG, Barry, MK, Johnson, CD & Sarr, MG 1999, 'Pancreas regeneration after resection: Does it occur in humans?', Pancreas, vol. 19, no. 3, pp. 310-313.
Tsiotos GG, Barry MK, Johnson CD, Sarr MG. Pancreas regeneration after resection: Does it occur in humans? Pancreas. 1999 Oct;19(3):310-313.
Tsiotos, Gregory G. ; Barry, M. Kevin ; Johnson, C. Daniel ; Sarr, Michael G. / Pancreas regeneration after resection : Does it occur in humans?. In: Pancreas. 1999 ; Vol. 19, No. 3. pp. 310-313.
@article{e2c30ed5ade84c7294e5ee89ee857969,
title = "Pancreas regeneration after resection: Does it occur in humans?",
abstract = "Although pancreatic regeneration after partial resection or pancreatic injury (restitutio ad integrum) has been demonstrated in animal models, whether regeneration occurs in the human pancreas is unknown. Our aim was to determine whether the human pancreas regenerates after subtotal resection We reviewed pre- and postoperative computerized tomograms (CTs) of 21 patients after proximal pancreatectomy (5060{\%} resection) for malignancy with no recurrent disease during follow-up of pancreatic parenchymal abnormalities. Three fixed anatomic measurements (pancreatic body width, tail width, and length) were compared with the same region 10 and 21 months after surgery. Data are expressed as mean ± SEM. Pancreatic measurements before and 10 months after resection did not differ for body width (2.0 ± 0.1 cm vs. 1.8 ± 0.1 cm), tail width (2.2 ± 0.2 cm vs. 1.8 ± 0.2 cm) or length (8.2 ± 0.3 vs. 7.4 ± 0.4 cm) (p ≥ 0.1 each). At 21 months after resection, measurements were less for body width and tall width (2.2 ± 0.2 cm vs. 1.5 ± 0.2 cm and 2.2 ± 0.1 cm vs. 1.5 ± 0.2 cm, respectively; p = 0.01) and unchanged for length (8.1 ± 0.4 cm vs. 81 ± 0.4 cm; p = 0.9). We conclude that the human pancreas does not regenerate after partial anatomic (50{\%}) resection.",
keywords = "Pancreas, Regeneration",
author = "Tsiotos, {Gregory G.} and Barry, {M. Kevin} and Johnson, {C. Daniel} and Sarr, {Michael G.}",
year = "1999",
month = "10",
language = "English (US)",
volume = "19",
pages = "310--313",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Pancreas regeneration after resection

T2 - Does it occur in humans?

AU - Tsiotos, Gregory G.

AU - Barry, M. Kevin

AU - Johnson, C. Daniel

AU - Sarr, Michael G.

PY - 1999/10

Y1 - 1999/10

N2 - Although pancreatic regeneration after partial resection or pancreatic injury (restitutio ad integrum) has been demonstrated in animal models, whether regeneration occurs in the human pancreas is unknown. Our aim was to determine whether the human pancreas regenerates after subtotal resection We reviewed pre- and postoperative computerized tomograms (CTs) of 21 patients after proximal pancreatectomy (5060% resection) for malignancy with no recurrent disease during follow-up of pancreatic parenchymal abnormalities. Three fixed anatomic measurements (pancreatic body width, tail width, and length) were compared with the same region 10 and 21 months after surgery. Data are expressed as mean ± SEM. Pancreatic measurements before and 10 months after resection did not differ for body width (2.0 ± 0.1 cm vs. 1.8 ± 0.1 cm), tail width (2.2 ± 0.2 cm vs. 1.8 ± 0.2 cm) or length (8.2 ± 0.3 vs. 7.4 ± 0.4 cm) (p ≥ 0.1 each). At 21 months after resection, measurements were less for body width and tall width (2.2 ± 0.2 cm vs. 1.5 ± 0.2 cm and 2.2 ± 0.1 cm vs. 1.5 ± 0.2 cm, respectively; p = 0.01) and unchanged for length (8.1 ± 0.4 cm vs. 81 ± 0.4 cm; p = 0.9). We conclude that the human pancreas does not regenerate after partial anatomic (50%) resection.

AB - Although pancreatic regeneration after partial resection or pancreatic injury (restitutio ad integrum) has been demonstrated in animal models, whether regeneration occurs in the human pancreas is unknown. Our aim was to determine whether the human pancreas regenerates after subtotal resection We reviewed pre- and postoperative computerized tomograms (CTs) of 21 patients after proximal pancreatectomy (5060% resection) for malignancy with no recurrent disease during follow-up of pancreatic parenchymal abnormalities. Three fixed anatomic measurements (pancreatic body width, tail width, and length) were compared with the same region 10 and 21 months after surgery. Data are expressed as mean ± SEM. Pancreatic measurements before and 10 months after resection did not differ for body width (2.0 ± 0.1 cm vs. 1.8 ± 0.1 cm), tail width (2.2 ± 0.2 cm vs. 1.8 ± 0.2 cm) or length (8.2 ± 0.3 vs. 7.4 ± 0.4 cm) (p ≥ 0.1 each). At 21 months after resection, measurements were less for body width and tall width (2.2 ± 0.2 cm vs. 1.5 ± 0.2 cm and 2.2 ± 0.1 cm vs. 1.5 ± 0.2 cm, respectively; p = 0.01) and unchanged for length (8.1 ± 0.4 cm vs. 81 ± 0.4 cm; p = 0.9). We conclude that the human pancreas does not regenerate after partial anatomic (50%) resection.

KW - Pancreas

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=0032830292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032830292&partnerID=8YFLogxK

M3 - Article

C2 - 10505763

AN - SCOPUS:0032830292

VL - 19

SP - 310

EP - 313

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 3

ER -