Pancreas and Islet Allograft Failure

Patrick G. Dean, Yogish Kudva, Mark D. Stegall

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The treatment of diabetes mellitus is aimed at improving glycemic control. Establishing relatively tight control using exogenous insulin has been shown to reduce the ophthal-mologic, neurologic and renal complications of diabetes mellitus.1 However, achieving a glycosylated hemoglobin (Hgb A1C) level low enough to reduce secondary complications (a level of approximately 7.0%) is associated with an increased risk of severe, life-threatening hypoglycemia. Both whole organ pancreas transplantation and isolated islet transplantation offer the possibility of even better glycemic control (average Hgb A1C < 6.0%) with the addition of counter-regulatory feedback hormones that avoid life-threatening hypoglycemia.

Original languageEnglish (US)
Title of host publicationChronic Allograft Failure
Subtitle of host publicationNatural History, Pathogenesis, Diagnosis and Management
PublisherCRC Press
Pages247-251
Number of pages5
ISBN (Electronic)9781498712729
ISBN (Print)9781587061530
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Dean, P. G., Kudva, Y., & Stegall, M. D. (2008). Pancreas and Islet Allograft Failure. In Chronic Allograft Failure: Natural History, Pathogenesis, Diagnosis and Management (pp. 247-251). CRC Press. https://doi.org/10.1201/9781498712729-40