Palliative splenectomy in myelofibrosis with myeloid metaplasia

R. A. Mesa, Ayalew Tefferi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Myelofibrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder in which the accumulation and growth of circulating myeloid progenitors in the spleen lead to pathologic enlargement of the organ with resulting mechanical discomfort, hypercatabolic symptoms, anemia, thrombocytopenia, and portal hypertension. Medical therapy and splenic irradiation may be of benefit in certain patients, yet many may still require splenectomy to palliate their symptoms. Although there is no clear survival advantage to splenectomy in MMM, the procedure can result in substantial palliation of symptoms. However, the surgical procedure is associated with an approximately 9% mortality rate, and the postsplenectomy occurrence of extreme thrombocytosis, hepatomegaly, and leukemic transformation is of major concern. The management of splenomegaly and the role of splenectomy in MMM are discussed in this review.

Original languageEnglish (US)
Pages (from-to)901-911
Number of pages11
JournalLeukemia and Lymphoma
Volume42
Issue number5
StatePublished - 2001

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Keywords

  • Myelofibrosis
  • Myeloid metaplasia
  • Splenectomy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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