Palliative oncology: Thalidomide

Eric E. Prommer

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

After decades of disuse because of its teratogenic effects, thalidomide has had a resurgence of use as a promising therapeutic agent for multiple myeloma. Its mechanism of action involves activation of the immune system, antiangiogenic effects, and inhibition of cytokines. Thalidomide does not interact with the cytochrome oxidase system. It is not significantly metabolized, but it does undergo nonenzymatic hydrolysis in plasma. The resulting products are inactive. Despite the potential adverse effects of peripheral neuropathy, constipation, deep vein thrombosis, somnolence, rash, and orthostatic hypotension, thalidomide is an effective first-line agent for multiple myeloma in combination with dexamethasone or melphalan and prednisone. It has also been studied in the palliative care of patients with cytokine-based syndromes such as anorexia-cachexia syndrome. This review describes its use in oncology, hematology, and palliative care.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalAmerican Journal of Hospice and Palliative Medicine
Volume27
Issue number3
DOIs
StatePublished - May 1 2010

Keywords

  • Anorexia-cachexia
  • Cytokines
  • Thalidomide

ASJC Scopus subject areas

  • Medicine(all)

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