Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia

W. Michael Hooten, Jolene M. Smith, Jason S. Eldrige, David A. Olsen, W. David Mauck, Susan M. Moeschler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The associations between pain, lower extremity strength, and aerobic conditioning have not been widely investigated in adults with fibromyalgia (FM). The principle objective of this study was to investigate the relationship between pain severity and knee strength in patients seeking treatment for FM. A secondary objective was to investigate the relationship between pain scores and aerobic conditioning. Methods: Three measures of knee strength (isokinetic extensor, isokinetic flexor, isometric extensor) were quantified in the dominant leg of 69 adults with FM using a dynamometer at speeds of 60 degrees per second (60°/s) and 180°/s. Peak oxygen uptake (VO2) was assessed using a cycle ergometer, and pain was assessed using the pain severity subscale of the Multidimensional Pain Inventory. Results: In univariable linear regression analyses using pain severity as the dependent variable, lesser values of isokinetic knee extensor strength at 60°/s (P=0.041) and 180°/s (P=0.010), isokinetic knee flexor strength at 60°/s (P=0.028) and 180°/s (P=0.003), and peak VO2 uptake (P=0.031) were predictive of greater pain severity scores. In multiple variable linear regression models adjusted for age, sex, body mass index, and opioid use, the following associations retained statistical significance; isokinetic knee extensor strength at 60°/s (P=0.020) and 180°/s (P=0.003), isokinetic knee flexor strength at 60°/s (P=0.015) and 180°/s (P=0.001), and peak VO2 uptake (P=0.014). However, no significant associations were found between pain severity and isometric knee extensor strength. Conclusion: The main findings from this study were that lesser values of isokinetic knee strength and peak VO2 uptake were predictive of greater pain severity scores. These results build on the findings of previous investigations, but ongoing research is needed to further characterize the effects of strength and peak VO2 uptake on the pathophysiology of FM.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalJournal of Pain Research
Volume7
DOIs
StatePublished - May 3 2014

Fingerprint

Fibromyalgia
Muscle Strength
Oxygen
Knee
Pain
Linear Models
Opioid Analgesics
Lower Extremity
Leg
Body Mass Index
Regression Analysis
Equipment and Supplies

Keywords

  • Fibromyalgia
  • Isokinetic
  • Knee extensor strength
  • Knee flexor strength
  • Peak oxygen uptake

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Hooten, W. M., Smith, J. M., Eldrige, J. S., Olsen, D. A., Mauck, W. D., & Moeschler, S. M. (2014). Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia. Journal of Pain Research, 7, 237-242. https://doi.org/10.2147/JPR.S61312

Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia. / Hooten, W. Michael; Smith, Jolene M.; Eldrige, Jason S.; Olsen, David A.; Mauck, W. David; Moeschler, Susan M.

In: Journal of Pain Research, Vol. 7, 03.05.2014, p. 237-242.

Research output: Contribution to journalArticle

Hooten, WM, Smith, JM, Eldrige, JS, Olsen, DA, Mauck, WD & Moeschler, SM 2014, 'Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia', Journal of Pain Research, vol. 7, pp. 237-242. https://doi.org/10.2147/JPR.S61312
Hooten, W. Michael ; Smith, Jolene M. ; Eldrige, Jason S. ; Olsen, David A. ; Mauck, W. David ; Moeschler, Susan M. / Pain severity is associated with muscle strength and peak oxygen uptake in adults with fibromyalgia. In: Journal of Pain Research. 2014 ; Vol. 7. pp. 237-242.
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abstract = "Background: The associations between pain, lower extremity strength, and aerobic conditioning have not been widely investigated in adults with fibromyalgia (FM). The principle objective of this study was to investigate the relationship between pain severity and knee strength in patients seeking treatment for FM. A secondary objective was to investigate the relationship between pain scores and aerobic conditioning. Methods: Three measures of knee strength (isokinetic extensor, isokinetic flexor, isometric extensor) were quantified in the dominant leg of 69 adults with FM using a dynamometer at speeds of 60 degrees per second (60°/s) and 180°/s. Peak oxygen uptake (VO2) was assessed using a cycle ergometer, and pain was assessed using the pain severity subscale of the Multidimensional Pain Inventory. Results: In univariable linear regression analyses using pain severity as the dependent variable, lesser values of isokinetic knee extensor strength at 60°/s (P=0.041) and 180°/s (P=0.010), isokinetic knee flexor strength at 60°/s (P=0.028) and 180°/s (P=0.003), and peak VO2 uptake (P=0.031) were predictive of greater pain severity scores. In multiple variable linear regression models adjusted for age, sex, body mass index, and opioid use, the following associations retained statistical significance; isokinetic knee extensor strength at 60°/s (P=0.020) and 180°/s (P=0.003), isokinetic knee flexor strength at 60°/s (P=0.015) and 180°/s (P=0.001), and peak VO2 uptake (P=0.014). However, no significant associations were found between pain severity and isometric knee extensor strength. Conclusion: The main findings from this study were that lesser values of isokinetic knee strength and peak VO2 uptake were predictive of greater pain severity scores. These results build on the findings of previous investigations, but ongoing research is needed to further characterize the effects of strength and peak VO2 uptake on the pathophysiology of FM.",
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