Pain and activity measurements

David H.H. Molstad, Elizabeth W. Bradley

Research output: Chapter in Book/Report/Conference proceedingChapter


Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Evoked pain
  • Functional assays
  • Incapacitance
  • Mechanical allodynia
  • Open-field activity assays
  • Static weight bearing
  • von Frey

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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