Paget's disease of the breast: A clinical perspective

George H. Sakorafas, D. Kay Blanchard, Michael G. Sarr, David R. Parley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Paget's disease of the breast is a rare disorder of the nipple-areola complex often associated with an underlying in situ or invasive carcinoma. Eczematoid changes of the nipple-areola complex and persistent soreness or itching should raise suspicion of this disease. The histogenesis of Paget's disease of the breast continues to be debated and is important when considering treatment options. The epidermotropic theory suggests that Paget's cells are ductal carcinoma cells that have migrated from an underlying carcinoma of the breast parenchyma to the epidermis of the nipple. The in situ transformation theory has been proposed to explain the development of this disorder in patients in whom an underlying mammary carcinoma is not found or when there is an underlying carcinoma anatomically remote from the nipple-areola complex. Paget's cells are believed to arise as malignant cells in the epidermis of the nipple independent from any other pathologic process within the breast parenchyma. The current standard treatment of biopsy-proven Paget's disease involves mastectomy, although some studies have proposed the use of breast conservation therapy for patients in whom an underlying breast cancer cannot be located. We propose a treatment algorithm for patients presenting with Paget's disease of the breast.

Original languageEnglish (US)
Pages (from-to)444-450
Number of pages7
JournalLangenbeck's Archives of Surgery
Volume386
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Mammary Paget's Disease
Nipples
Breast Neoplasms
Epidermis
Carcinoma
Ductal Carcinoma
Segmental Mastectomy
Mastectomy
Pathologic Processes
Pruritus
Breast
Therapeutics
Biopsy

Keywords

  • Breast
  • Paget's disease

ASJC Scopus subject areas

  • Surgery

Cite this

Sakorafas, G. H., Kay Blanchard, D., Sarr, M. G., & Parley, D. R. (2001). Paget's disease of the breast: A clinical perspective. Langenbeck's Archives of Surgery, 386(6), 444-450. https://doi.org/10.1007/s004230100250

Paget's disease of the breast : A clinical perspective. / Sakorafas, George H.; Kay Blanchard, D.; Sarr, Michael G.; Parley, David R.

In: Langenbeck's Archives of Surgery, Vol. 386, No. 6, 2001, p. 444-450.

Research output: Contribution to journalArticle

Sakorafas, GH, Kay Blanchard, D, Sarr, MG & Parley, DR 2001, 'Paget's disease of the breast: A clinical perspective', Langenbeck's Archives of Surgery, vol. 386, no. 6, pp. 444-450. https://doi.org/10.1007/s004230100250
Sakorafas, George H. ; Kay Blanchard, D. ; Sarr, Michael G. ; Parley, David R. / Paget's disease of the breast : A clinical perspective. In: Langenbeck's Archives of Surgery. 2001 ; Vol. 386, No. 6. pp. 444-450.
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