Paclitaxel-coated balloon dilation for central airway obstruction

Kenneth K. Sakata, Darlene R. Nelson, John J. Mullon, David Eric Midthun, Eric Edell, Ryan M. Kern

Research output: Contribution to journalArticle

Abstract

Introduction: Central airway obstruction (CAO) often requires repeated interventional procedures which offer variable efficacy, a time-limited effect, and have inherent limitations. Paclitaxel has been used to prevent restenosis in blood vessels. The literature describing the use of paclitaxel to prevent recurrent airway stenosis is limited. We sought to describe our experience using a paclitaxel-coated balloon (PCB) for CAO. Material and methods: We performed a retrospective review of all patients who underwent PCB airway dilation. We collected: basic demographics, details of the CAO, details of the bronchoscopes used, PCB size, PCB dilation pressure, duration of PCB inflation, concurrent non-PCB interventions, estimated pre- and post-PCB CAO luminal diameter, follow up bronchoscopy date and luminal diameter, and spirometry results. Results: PCB dilation was performed in 10 cases on 5 patients. Eight PCB dilations were performed for CAO related to distal airway stent stenosis. Concurrent non-PCB interventions were performed with 6 PCB dilations. Nine cases documented improvements and 1 was unchanged immediately post-PCB dilation. Median luminal diameter pre-PCB dilation was 2 mm. Immediately post-PCB dilation, the median change in luminal diameter was 2 mm. Follow up bronchoscopy information was available for 9 cases. For these 9 cases, luminal diameter was unchanged in 5 and worse in 4 when compared to immediate post-PCB dilation. Conclusion: PCB dilation in benign CAO produced a modest effect in this cohort of challenging airways. Larger prospective studies are needed to assess how a PCB would perform when compared to a non-drug coated balloon.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalRespiratory Medicine Case Reports
Volume24
DOIs
StatePublished - Jan 1 2018

Fingerprint

Airway Obstruction
Paclitaxel
Dilatation
Bronchoscopy
Pathologic Constriction
Bronchoscopes
Cohort Effect
Spirometry
Polychlorinated Biphenyls
Economic Inflation

Keywords

  • Airway stenosis
  • Airway stricture
  • Balloon dilation
  • Central airway obstruction
  • Paclitaxel balloon dilation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Paclitaxel-coated balloon dilation for central airway obstruction. / Sakata, Kenneth K.; Nelson, Darlene R.; Mullon, John J.; Midthun, David Eric; Edell, Eric; Kern, Ryan M.

In: Respiratory Medicine Case Reports, Vol. 24, 01.01.2018, p. 129-132.

Research output: Contribution to journalArticle

Sakata, Kenneth K. ; Nelson, Darlene R. ; Mullon, John J. ; Midthun, David Eric ; Edell, Eric ; Kern, Ryan M. / Paclitaxel-coated balloon dilation for central airway obstruction. In: Respiratory Medicine Case Reports. 2018 ; Vol. 24. pp. 129-132.
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