The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.
|Original language||English (US)|
|Number of pages||7|
|Journal||Annals of the New York Academy of Sciences|
|State||Published - 1998|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science