p73 mutations are not detected in sporadic and hereditary breast cancer

David I. Schwartz, Noralane M. Lindor, Cate Walsh-Vockley, Patrick C. Roche, Mai Ming, David I. Smith, Liu Wanguo, Fergus J. Couch

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Recently, a novel tumor suppressor gene, p73, was isolated and mapped to chromosome 1p36, a region commonly associated with loss of heterozygosity in neuroblastoma and other human malignancies, including breast cancer. The p73 gene shares considerable homology with the common tumor suppressor gene p53, both in composition and function. This study examines the potential participation of p73 in the pathogenesis of sporadic and hereditary breast cancers. Mutation analysis of 29 hereditary breast cancer cases revealed five independent silent mutations in the hereditary cases that are unlikely to play a role in tumor development. Mutation analysis of 48 sporadic breast tumors did not identify any unique variants. Eleven common polymorphisms scattered throughout the gene were also detected. Thus, mutations in the p73 gene appear to play little if any role in hereditary or sporadic breast cancer.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalBreast Cancer Research and Treatment
Volume58
Issue number1
DOIs
StatePublished - Dec 1 1999

Keywords

  • Breast cancer
  • Mutation
  • Sporadic
  • p73

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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