p53 mutations in carcinoma of the esophagus and gastroesophageal junction

C. Sengpiel; I. R. Konig; D. Rades; F. Noack; M. Duchrow; S. E. Schild; D. Ludwig; N. Homann

doi:10.1080/07357900802161047

p53 mutations in carcinoma of the esophagus and gastroesophageal junction

C. Sengpiel, I. R. Konig, D. Rades, F. Noack, M. Duchrow, S. E. Schild, D. Ludwig, N. Homann

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.

Original language	English (US)
Pages (from-to)	96-104
Number of pages	9
Journal	Cancer Investigation
Volume	27
Issue number	1
DOIs	https://doi.org/10.1080/07357900802161047
State	Published - Jan 2009

Keywords

Alcohol
Esophageal cancer
Tobacco
p53 gene

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357900802161047

Cite this

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title = "p53 mutations in carcinoma of the esophagus and gastroesophageal junction",

abstract = "Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.",

keywords = "Alcohol, Esophageal cancer, Tobacco, p53 gene",

author = "C. Sengpiel and Konig, {I. R.} and D. Rades and F. Noack and M. Duchrow and Schild, {S. E.} and D. Ludwig and N. Homann",

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T1 - p53 mutations in carcinoma of the esophagus and gastroesophageal junction

AU - Sengpiel, C.

AU - Konig, I. R.

AU - Rades, D.

AU - Noack, F.

AU - Duchrow, M.

AU - Schild, S. E.

AU - Ludwig, D.

AU - Homann, N.

PY - 2009/1

Y1 - 2009/1

N2 - Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.

AB - Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.

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KW - Esophageal cancer

KW - Tobacco

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p53 mutations in carcinoma of the esophagus and gastroesophageal junction

Abstract

Keywords

ASJC Scopus subject areas

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