P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

Medicine & Life Sciences

• N-(2-chloro-3-(trifluoromethyl)benzyl)-N-methyl-5-oxopyrrolidine-2-carboxamide 100%
• Exosomes 50%
• Transgenic Mice 38%
• Microglia 32%
• Phenotype 25%
• Tauopathies 21%
• Neurons 13%
• Astrocytes 9%
• Oral Administration 9%
• Purinergic P2X Receptors 8%
• Adenosine Triphosphate 8%
• Frontotemporal Dementia 6%
• Microtubule-Associated Proteins 6%
• Neuropathology 5%
• Cations 5%
• Short-Term Memory 5%
• Ligation 4%
• In Vitro Techniques 4%
• Fear 4%
• Therapeutic Uses 4%
• Psychological Inhibition 4%
• Alzheimer Disease 4%
• Anti-Inflammatory Agents 3%
• Memory 3%
• Therapeutics 3%
• Pathology 3%
• Cytokines 3%
• Gene Expression 3%