p16 methylation of the colorectal cancer and association with Dukes stages

Zhi Wei Wang, Jing Yi, Hui Cang, Hong Zhi Zou, Bao Ming Yu, Xue Ming Tang

Research output: Contribution to journalArticle

Abstract

Objective: To explore whether methylation of the CpG island in the promoter of the p16 tumor suppressor gene was associated with clinicopathological characteristics of the colorectal cancer patients. Methods: Methylation-specific PCR (MSP) was used to detect p16 methylation of the colorectal cancer patients. Results: In 58 sporadic colorectal cancer, 43.1% of the tumors had detectable p16 methylation. Dukes' stage was associated with p16 methylation status. Dukes C, D patients (75%) were more likely to contain methylated p16 compared with Dukes A, B patients (13.3%). Conclusion: P16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer. P16 methylation might be considered as a prognostic indicator.

Original languageEnglish (US)
Pages (from-to)288-290
Number of pages3
JournalChinese Journal of Cancer Research
Volume13
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Colorectal cancer
  • MSP
  • Methylation
  • p16 CpG region

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'p16 methylation of the colorectal cancer and association with Dukes stages'. Together they form a unique fingerprint.

  • Cite this