@article{e2c1556529d34e93995bd1c94879d3c3,
title = "p16 methylation of the colorectal cancer and association with Dukes stages",
abstract = "Objective: To explore whether methylation of the CpG island in the promoter of the p16 tumor suppressor gene was associated with clinicopathological characteristics of the colorectal cancer patients. Methods: Methylation-specific PCR (MSP) was used to detect p16 methylation of the colorectal cancer patients. Results: In 58 sporadic colorectal cancer, 43.1% of the tumors had detectable p16 methylation. Dukes' stage was associated with p16 methylation status. Dukes C, D patients (75%) were more likely to contain methylated p16 compared with Dukes A, B patients (13.3%). Conclusion: P16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer. P16 methylation might be considered as a prognostic indicator.",
keywords = "Colorectal cancer, MSP, Methylation, p16 CpG region",
author = "Wang, {Zhi Wei} and Jing Yi and Hui Cang and Zou, {Hong Zhi} and Yu, {Bao Ming} and Tang, {Xue Ming}",
note = "Funding Information: Since its discovery as a CDKi (cyclin-dependent kinase inhibitor) in 1993, the tumor suppressor p16 (INK4/MTS1/CDKN2A) has been found to play an important role in carcinogenesis [l'a]. A high frequency of p16 gene alterations were observed in many tumors. P16 gene alterations have at least three ways: homozygous deletion, point mutation and methylation of the promoter TM. The first two mechanisms have never been found in colorectal cancer t3-Sj. The role of p16 gene Received date: April 18, 2001, Accepted date: September 7, 2001. Foundation item: This work was supported by a grant from Ministry of Public Health of China (No. 98-1-303) and The Education Committee of Shanghai(No. 1 2000B02). *Author to whom correspondence should be addressed. Phone: (0086-21)-63846590 ext. 421; Fax: (0086-21)-53065329; E-mail: swwl@shsmu.edu.cn Biography: WANG Zhi-wei(1970-), master of medicine, Department of Cell Biology, Shanghai Second Medical University, majors in cell biology of cancer.",
year = "2001",
doi = "10.1007/s11670-001-0050-8",
language = "English (US)",
volume = "13",
pages = "288--290",
journal = "Chinese Journal of Cancer Research",
issn = "1000-9604",
publisher = "Beijing Institute for Cancer Research",
number = "4",
}