p16 methylation of the colorectal cancer and association with Dukes stages

Z. W. Wang, J. Yi, H. Cang, H. Z. Zou, B. M. Yu, X. M. Tang

Research output: Contribution to journalArticle

Abstract

Objective: To explore whether methylation of the CpG island in the promoter of the p16 tumor suppressor gene was associated with clinicopathological characteristics of the colorectal cancer patients. Methods: Methylation-specific PCR (MSP) was used to detect p16 methylation of the colorectal cancer patients. Results: In 58 sporadic colorectal cancer, 43.1% of the tumors had detectable p16 methylation. Dukes' stage was associated with p16 methylation status. Dukes C, D patients (75%) were more likely to contain methylated p16 compared with Dukes A, B patients (13.3%). Conclusion: P16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer. P16 methylation might be considered as a prognostic indicator.

Original languageEnglish (US)
Pages (from-to)288-290
Number of pages3
JournalChinese Journal of Cancer Research
Volume13
Issue number4
StatePublished - 2001
Externally publishedYes

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Methylation
Colorectal Neoplasms
CpG Islands
Tumor Suppressor Genes
Carcinogenesis
Polymerase Chain Reaction
Neoplasms

Keywords

  • Colorectal cancer
  • Methylation
  • MSP
  • p16 CpG region

ASJC Scopus subject areas

  • Cancer Research

Cite this

Wang, Z. W., Yi, J., Cang, H., Zou, H. Z., Yu, B. M., & Tang, X. M. (2001). p16 methylation of the colorectal cancer and association with Dukes stages. Chinese Journal of Cancer Research, 13(4), 288-290.

p16 methylation of the colorectal cancer and association with Dukes stages. / Wang, Z. W.; Yi, J.; Cang, H.; Zou, H. Z.; Yu, B. M.; Tang, X. M.

In: Chinese Journal of Cancer Research, Vol. 13, No. 4, 2001, p. 288-290.

Research output: Contribution to journalArticle

Wang, ZW, Yi, J, Cang, H, Zou, HZ, Yu, BM & Tang, XM 2001, 'p16 methylation of the colorectal cancer and association with Dukes stages', Chinese Journal of Cancer Research, vol. 13, no. 4, pp. 288-290.
Wang, Z. W. ; Yi, J. ; Cang, H. ; Zou, H. Z. ; Yu, B. M. ; Tang, X. M. / p16 methylation of the colorectal cancer and association with Dukes stages. In: Chinese Journal of Cancer Research. 2001 ; Vol. 13, No. 4. pp. 288-290.
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