TY - JOUR
T1 - P-selectin and subclinical and clinical atherosclerosis
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Bielinski, Suzette J.
AU - Berardi, Cecilia
AU - Decker, Paul A.
AU - Kirsch, Phillip S.
AU - Larson, Nicholas B.
AU - Pankow, James S.
AU - Sale, Michele
AU - de Andrade, Mariza
AU - Sicotte, Hugues
AU - Tang, Weihong
AU - Hanson, Naomi Q.
AU - Wassel, Christina L.
AU - Polak, Joseph F.
AU - Tsai, Michael Y.
N1 - Funding Information:
This study was funded by MESA. MESA is conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with MESA investigators (Grants and contracts N01 HC-95159 , N01-HC-95160 , N01-HC-95161 , N01-HC-95162 , N01-HC-95163 , N01-HC-95164 , N01-HC-95165 , N01-HC-95166 , N01-HC-95167 , N01-HC-95168 , N01-HC-95169 and RR-024156 ). Funding to support adhesion protein measurements was provided by NHLBI ( R01 HL98077 , for abdominal aortic CT by grant R01 HL088451, and for IMT measurements by grants R01 HL069003 and R01 HL081352).
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events. Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027). Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.
AB - Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events. Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027). Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.
KW - Atherosclerosis
KW - Cardiovascular risk factors
KW - Coronary artery calcium
KW - P-selectin
UR - http://www.scopus.com/inward/record.url?scp=84923853337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923853337&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2015.02.036
DO - 10.1016/j.atherosclerosis.2015.02.036
M3 - Article
C2 - 25744700
AN - SCOPUS:84923853337
SN - 0021-9150
VL - 240
SP - 3
EP - 9
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -