Oxygen in stem cell biology: A critical component of the stem cell niche

Ahmed Mohyeldin, Tomás Garzón-Muvdi, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalReview article

884 Scopus citations

Abstract

The defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment. Recent evidence has identified a broader spectrum of stem cells influenced by hypoxia that includes cancer stem cells and induced pluripotent stem cells. These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche.

Original languageEnglish (US)
Pages (from-to)150-161
Number of pages12
JournalCell Stem Cell
Volume7
Issue number2
DOIs
StatePublished - Aug 6 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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