Oxygen free radical effects in sciatic nerve in experimental diabetes

Phillip Anson Low, K. K. Nickander

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

We previously reported the presence of endoneurial hypoxia, ischemia, impairment of the blood-nerve barrier, and reduction of norepinephrine and 6-ketoprostaglandin F(1α) in chronic streptozocin-induced diabetic neuropathy (SDN) and interpreted these findings as suggesting the involvement of oxygen free radicals (OFRs) but did not directly measure indices of OFR activity. In this study, we report on sciatic nerve conjugated dienes, hydroperoxides, norepinephrine, and malondialdehyde in SDN at 1, 4, and 12 mo in male Sprague-Dawley rats. Severe hyperglycemia was present throughout in diabetic rats. Conjugated dienes were consistently increased at all time points, hydroperoxides were consistently reduced, and malondialdehyde was not significantly different in diabetes compared with controls. These findings are consistent with increased OFR activity in experimental diabetes. It is necessary to monitor several indices of OFR activity in a metabolically active tissue such as the peripheral nerve.

Original languageEnglish (US)
Pages (from-to)873-877
Number of pages5
JournalDiabetes
Volume40
Issue number7
StatePublished - 1991

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Sciatic Nerve
Free Radicals
Reactive Oxygen Species
Diabetic Neuropathies
Streptozocin
Malondialdehyde
Hydrogen Peroxide
Norepinephrine
Blood-Nerve Barrier
Peripheral Nerves
Hyperglycemia
Sprague Dawley Rats
Ischemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Oxygen free radical effects in sciatic nerve in experimental diabetes. / Low, Phillip Anson; Nickander, K. K.

In: Diabetes, Vol. 40, No. 7, 1991, p. 873-877.

Research output: Contribution to journalArticle

Low, PA & Nickander, KK 1991, 'Oxygen free radical effects in sciatic nerve in experimental diabetes', Diabetes, vol. 40, no. 7, pp. 873-877.
Low, Phillip Anson ; Nickander, K. K. / Oxygen free radical effects in sciatic nerve in experimental diabetes. In: Diabetes. 1991 ; Vol. 40, No. 7. pp. 873-877.
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