Oxygen-Exacerbated Bleomycin Pulmonary Toxicity

THEODORE S. INGRASSIA, JAY H. RYU, VICTOR F. TRASTEK, EDWARD C. ROSENOW

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen. We report a case in which the intraoperative administration of oxygen in the setting of previous bleomycin therapy contributed to postoperative ventilatory failure. Our patient recovered with corticosteroid therapy. Physician awareness of a potential interaction between oxygen and bleomycin may help reduce the morbidity and mortality related to bleomycin therapy.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalMayo Clinic proceedings
Volume66
Issue number2
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Medicine(all)

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    INGRASSIA, THEODORE. S., RYU, JAY. H., TRASTEK, VICTOR. F., & ROSENOW, EDWARD. C. (1991). Oxygen-Exacerbated Bleomycin Pulmonary Toxicity. Mayo Clinic proceedings, 66(2), 173-178. https://doi.org/10.1016/S0025-6196(12)60489-3