Oxygen enhanced MR ventilation imaging of the lung

Qun Chen, Peter M. Jakob, Mark A. Griswold, David L. Levin, Hiroto Hatabu, Robert R. Edelman

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

The current work is a continuation of a new MRI technique that was proposed for the non-invasive assessment of regional lung ventilation using inhaled molecular oxygen as a T1 contrast agent. Several improvements of this technique are described in this work. The signal-to-noise ratio in the ventilation-scan images was optimized using a centrically reordered single- shot RARE sequence with a short effective echo time and short inter-echo spacing. The contrast-to-noise ratio was improved using an optimized inversion delay time. The optimized MR-ventilation-scan was successfully performed in healthy volunteers and in an animal model with airway obstruction. The experimental results demonstrate the feasibility and clinical potential of the MR ventilation imaging technique for assessment of regional pulmonary function.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume7
Issue number3
DOIs
StatePublished - Dec 14 1998

Keywords

  • Inversion recovery
  • Lung, Ventilation
  • MRI
  • Oxygen enhancement

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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