Oxygen-derived free radicals and acute pancreatitis

a review.

H. Sanfey, M. G. Sarr, G. B. Bulkley, J. L. Cameron

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis has been investigated in a series of studies using an ex vivo, perfused canine pancreas preparation. Three models of experimental acute pancreatitis have been developed in this preparation: ischemic pancreatitis, gallstone pancreatitis, and alcohol-induced pancreatitis. In each model, the pancreas becomes edematous, gains weight, and the perfusate develops hyperamylasemia during the 4 hour period of perfusion. Pretreatment with the free radical scavengers superoxide dismutase and catalase significantly ameliorates these manifestations of pancreatic injury in each of the three models. The source of the free radical generation was investigated by pretreating the preparation with allopurinol, a quite specific inhibitor of xanthine oxidase. In each of the three models, this also significantly ameliorated the injury process. These experiments demonstrate that oxygen-derived free radicals, generated by activated xanthine oxidase, appear to play a central role in the pathogenesis of acute pancreatitis in these models. These findings shed light on the fundamental pathophysiology of this disease and may provide the basis for more effective therapy in the future.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalActa physiologica Scandinavica. Supplementum
Volume548
StatePublished - 1986
Externally publishedYes

Fingerprint

Pancreatitis
Free Radicals
Oxygen
Xanthine Oxidase
Pancreas
Hyperamylasemia
Free Radical Scavengers
Allopurinol
Wounds and Injuries
Gallstones
Catalase
Superoxide Dismutase
Weight Gain
Canidae
Theoretical Models
Perfusion
Alcohols

ASJC Scopus subject areas

  • Physiology

Cite this

Sanfey, H., Sarr, M. G., Bulkley, G. B., & Cameron, J. L. (1986). Oxygen-derived free radicals and acute pancreatitis: a review. Acta physiologica Scandinavica. Supplementum, 548, 109-118.

Oxygen-derived free radicals and acute pancreatitis : a review. / Sanfey, H.; Sarr, M. G.; Bulkley, G. B.; Cameron, J. L.

In: Acta physiologica Scandinavica. Supplementum, Vol. 548, 1986, p. 109-118.

Research output: Contribution to journalArticle

Sanfey, H, Sarr, MG, Bulkley, GB & Cameron, JL 1986, 'Oxygen-derived free radicals and acute pancreatitis: a review.', Acta physiologica Scandinavica. Supplementum, vol. 548, pp. 109-118.
Sanfey, H. ; Sarr, M. G. ; Bulkley, G. B. ; Cameron, J. L. / Oxygen-derived free radicals and acute pancreatitis : a review. In: Acta physiologica Scandinavica. Supplementum. 1986 ; Vol. 548. pp. 109-118.
@article{c6f1a1deb32f49369557dcbf900237fc,
title = "Oxygen-derived free radicals and acute pancreatitis: a review.",
abstract = "The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis has been investigated in a series of studies using an ex vivo, perfused canine pancreas preparation. Three models of experimental acute pancreatitis have been developed in this preparation: ischemic pancreatitis, gallstone pancreatitis, and alcohol-induced pancreatitis. In each model, the pancreas becomes edematous, gains weight, and the perfusate develops hyperamylasemia during the 4 hour period of perfusion. Pretreatment with the free radical scavengers superoxide dismutase and catalase significantly ameliorates these manifestations of pancreatic injury in each of the three models. The source of the free radical generation was investigated by pretreating the preparation with allopurinol, a quite specific inhibitor of xanthine oxidase. In each of the three models, this also significantly ameliorated the injury process. These experiments demonstrate that oxygen-derived free radicals, generated by activated xanthine oxidase, appear to play a central role in the pathogenesis of acute pancreatitis in these models. These findings shed light on the fundamental pathophysiology of this disease and may provide the basis for more effective therapy in the future.",
author = "H. Sanfey and Sarr, {M. G.} and Bulkley, {G. B.} and Cameron, {J. L.}",
year = "1986",
language = "English (US)",
volume = "548",
pages = "109--118",
journal = "Acta Physiologica Scandinavica, Supplement",
issn = "0302-2994",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Oxygen-derived free radicals and acute pancreatitis

T2 - a review.

AU - Sanfey, H.

AU - Sarr, M. G.

AU - Bulkley, G. B.

AU - Cameron, J. L.

PY - 1986

Y1 - 1986

N2 - The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis has been investigated in a series of studies using an ex vivo, perfused canine pancreas preparation. Three models of experimental acute pancreatitis have been developed in this preparation: ischemic pancreatitis, gallstone pancreatitis, and alcohol-induced pancreatitis. In each model, the pancreas becomes edematous, gains weight, and the perfusate develops hyperamylasemia during the 4 hour period of perfusion. Pretreatment with the free radical scavengers superoxide dismutase and catalase significantly ameliorates these manifestations of pancreatic injury in each of the three models. The source of the free radical generation was investigated by pretreating the preparation with allopurinol, a quite specific inhibitor of xanthine oxidase. In each of the three models, this also significantly ameliorated the injury process. These experiments demonstrate that oxygen-derived free radicals, generated by activated xanthine oxidase, appear to play a central role in the pathogenesis of acute pancreatitis in these models. These findings shed light on the fundamental pathophysiology of this disease and may provide the basis for more effective therapy in the future.

AB - The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis has been investigated in a series of studies using an ex vivo, perfused canine pancreas preparation. Three models of experimental acute pancreatitis have been developed in this preparation: ischemic pancreatitis, gallstone pancreatitis, and alcohol-induced pancreatitis. In each model, the pancreas becomes edematous, gains weight, and the perfusate develops hyperamylasemia during the 4 hour period of perfusion. Pretreatment with the free radical scavengers superoxide dismutase and catalase significantly ameliorates these manifestations of pancreatic injury in each of the three models. The source of the free radical generation was investigated by pretreating the preparation with allopurinol, a quite specific inhibitor of xanthine oxidase. In each of the three models, this also significantly ameliorated the injury process. These experiments demonstrate that oxygen-derived free radicals, generated by activated xanthine oxidase, appear to play a central role in the pathogenesis of acute pancreatitis in these models. These findings shed light on the fundamental pathophysiology of this disease and may provide the basis for more effective therapy in the future.

UR - http://www.scopus.com/inward/record.url?scp=0022482534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022482534&partnerID=8YFLogxK

M3 - Article

VL - 548

SP - 109

EP - 118

JO - Acta Physiologica Scandinavica, Supplement

JF - Acta Physiologica Scandinavica, Supplement

SN - 0302-2994

ER -