Oxygen cost of exercise hyperpnea

Measurement

E. A. Aaron, Bruce David Johnson, C. K. Seow, J. A. Dempsey

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

To quantitate the O 2 cost of maximal exercise hyperpnea, we required eight healthy adult subjects to mimic, at rest, the important mechanical components of submaximal and maximal exercise hyperpnea. Expired minute ventilation (V̇E), transpulmonary and trans-diaphragmatic (Pdi) pressures, and end-expiratory lung volume (EELV) were measured during exercise at 70 and 100% of maximal O 2 uptake. At rest, subjects were given visual feedback of their exercise transpulmonary pressure-tidal volume loop (Ẇ(v)), breathing frequency, and EELV, which they mimicked repeatedly for 5 min per trial over several trials, while hypocapnia was prevented. The change in total body O 2 uptake (V̇O 2) was measured and presumed to represent the O 2 cost of the hyperpnea. In 61 mimicking trials with V̇E of 115-167 l/min and Ẇ(v) of 124-544 J/min, V̇E, Ẇ(v), duty cycle of the breath, and expiratory gastric pressure (Pga) integrated with respect to time (∫Pga · dt/min) were not different from those observed during maximum exercise. ∫Pdi · dt/min was 14% less and EELV was 6% greater during maximum exercise than during mimicking. The O 2 cost measurements within a subject were reproducible over 3-12 trials (coefficient of variation ±10%, range 5-16%). The O 2 costs of hyperpnea correlated highly and positively with V̇E and Ẇ(v) and less, but significantly, with ∫Pdi · dt and ∫Pga · dt. The O 2 cost of V̇E rose out of proportion to the increasing hyperpnea, so that between 70 and 100% of maximal V̇O 2 ΔV̇O 2/ΔV̇E increased 40-60% (1.8 ± 0.2 to 2.9 ± 0.1 ml O 2/l V̇E) as V̇E doubled. We believe that these data provide a realistic conservative estimate of the actual cost of exercise hyperpnea over a broad range of ventilatory outputs during moderately heavy-to-maximum exercise in healthy human subjects.

Original languageEnglish (US)
Pages (from-to)1810-1817
Number of pages8
JournalJournal of Applied Physiology
Volume72
Issue number5
StatePublished - 1992
Externally publishedYes

Fingerprint

Ventilation
Exercise
Oxygen
Costs and Cost Analysis
Pressure
Lung
Healthy Volunteers
Hypocapnia
Sensory Feedback
Tidal Volume
Stomach
Respiration

Keywords

  • end-expiratory lung volume
  • expiratory muscles
  • inspiratory muscles
  • ventilatory work

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Aaron, E. A., Johnson, B. D., Seow, C. K., & Dempsey, J. A. (1992). Oxygen cost of exercise hyperpnea: Measurement. Journal of Applied Physiology, 72(5), 1810-1817.

Oxygen cost of exercise hyperpnea : Measurement. / Aaron, E. A.; Johnson, Bruce David; Seow, C. K.; Dempsey, J. A.

In: Journal of Applied Physiology, Vol. 72, No. 5, 1992, p. 1810-1817.

Research output: Contribution to journalArticle

Aaron, EA, Johnson, BD, Seow, CK & Dempsey, JA 1992, 'Oxygen cost of exercise hyperpnea: Measurement', Journal of Applied Physiology, vol. 72, no. 5, pp. 1810-1817.
Aaron, E. A. ; Johnson, Bruce David ; Seow, C. K. ; Dempsey, J. A. / Oxygen cost of exercise hyperpnea : Measurement. In: Journal of Applied Physiology. 1992 ; Vol. 72, No. 5. pp. 1810-1817.
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