Oxidative stress: Key player in gastrointestinal complications of diabetes

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Gastrointestinal dysmotility presenting as nausea, vomiting, bloating, diarrhea, constipation or abdominal pain is seen in diabetic patients. Oxidative stress has recently been recognized as a significant player in the pathogenesis of gastrointestinal complications of diabetes. In this issue of Neurogastroenterology and Motility, a team of investigators from Emory University led by Dr. Srinivasan present new evidence on the effect of oxidative stress in the diabetic colon. They show in diabetic patients, increased oxidative stress is associated with loss of the inhibitory neuronal subpopulation of enteric neurons, and that the neuronal loss can be reversed in-vitro by anti-oxidant lipoic acid. This new information adds to the accumulating evidence on the deleterious effect of oxidative stress in the gastrointestinal tract and highlights the opportunity to develop newer therapies focused on augmenting anti-oxidant defenses in the gastrointestinal tract in diabetic patients.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalNeurogastroenterology and Motility
Volume23
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Diabetes Complications
Oxidative Stress
Oxidants
Gastrointestinal Tract
Thioctic Acid
Constipation
Nausea
Abdominal Pain
Vomiting
Diarrhea
Colon
Research Personnel
Neurons
Therapeutics

Keywords

  • Diabetes
  • Heme oxygenase-1
  • Lipoic acid
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Oxidative stress : Key player in gastrointestinal complications of diabetes. / Kashyap, Purna C; Farrugia, Gianrico.

In: Neurogastroenterology and Motility, Vol. 23, No. 2, 02.2011, p. 111-114.

Research output: Contribution to journalArticle

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