Oxidative stress: Key player in gastrointestinal complications of diabetes

Research output: Contribution to journalComment/debatepeer-review

53 Scopus citations

Abstract

Gastrointestinal dysmotility presenting as nausea, vomiting, bloating, diarrhea, constipation or abdominal pain is seen in diabetic patients. Oxidative stress has recently been recognized as a significant player in the pathogenesis of gastrointestinal complications of diabetes. In this issue of Neurogastroenterology and Motility, a team of investigators from Emory University led by Dr. Srinivasan present new evidence on the effect of oxidative stress in the diabetic colon. They show in diabetic patients, increased oxidative stress is associated with loss of the inhibitory neuronal subpopulation of enteric neurons, and that the neuronal loss can be reversed in-vitro by anti-oxidant lipoic acid. This new information adds to the accumulating evidence on the deleterious effect of oxidative stress in the gastrointestinal tract and highlights the opportunity to develop newer therapies focused on augmenting anti-oxidant defenses in the gastrointestinal tract in diabetic patients.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalNeurogastroenterology and Motility
Volume23
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • Diabetes
  • Heme oxygenase-1
  • Lipoic acid
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Fingerprint Dive into the research topics of 'Oxidative stress: Key player in gastrointestinal complications of diabetes'. Together they form a unique fingerprint.

Cite this