Oxidative stress in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Increased oxidative stress is a common feature observed in many different types of cancer. Depending on the radical formed, its concentration, and cellular location where its generation occurs, reactive oxygen species (ROS) have multiple functions within tumor cells. ROS-induced macromolecule damage can contribute to tumor initiation. Low levels of ROS can initiate cellular signaling pathways that mediate tumor cell proliferation, survival and tumor progression to a metastatic phenotype. High levels of ROS initiate signaling pathways that mediate tumor cell death, but also contribute to formation of cancer stem cells that induce tumor recurrence. Understanding the multitude and complexity of ROS-regulated pathways in cancer cells and targeted modulation of intracellular ROS levels using antioxidants or chemotherapy at different stages of tumor progression may be an effective strategy for combination therapy.

Original languageEnglish (US)
Title of host publicationOxidative Stress and Redox Regulation
PublisherSpringer Netherlands
Pages427-447
Number of pages21
Volume9789400757875
ISBN (Print)9789400757875, 9400757867, 9789400757868
DOIs
StatePublished - Sep 1 2012

Fingerprint

Oxidative stress
Tumors
Oxidative Stress
Reactive Oxygen Species
Neoplasms
Cells
Cell signaling
Chemotherapy
Cell proliferation
Cell death
Stem cells
Macromolecules
Neoplastic Stem Cells
Antioxidants
Modulation
Cell Survival
Cell Death
Cell Proliferation
Phenotype
Recurrence

Keywords

  • Antioxidants
  • Cancer
  • Oxidative stress
  • Reactive oxygen species
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Storz, P. (2012). Oxidative stress in cancer. In Oxidative Stress and Redox Regulation (Vol. 9789400757875, pp. 427-447). Springer Netherlands. https://doi.org/10.1007/978-94-007-5787-5_15

Oxidative stress in cancer. / Storz, Peter.

Oxidative Stress and Redox Regulation. Vol. 9789400757875 Springer Netherlands, 2012. p. 427-447.

Research output: Chapter in Book/Report/Conference proceedingChapter

Storz, P 2012, Oxidative stress in cancer. in Oxidative Stress and Redox Regulation. vol. 9789400757875, Springer Netherlands, pp. 427-447. https://doi.org/10.1007/978-94-007-5787-5_15
Storz P. Oxidative stress in cancer. In Oxidative Stress and Redox Regulation. Vol. 9789400757875. Springer Netherlands. 2012. p. 427-447 https://doi.org/10.1007/978-94-007-5787-5_15
Storz, Peter. / Oxidative stress in cancer. Oxidative Stress and Redox Regulation. Vol. 9789400757875 Springer Netherlands, 2012. pp. 427-447
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