Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases

E. Trushina, C. T. McMurray

Research output: Contribution to journalReview articlepeer-review

303 Scopus citations

Abstract

In recent years, it has become increasingly clear that mitochondrial dysfunction and oxidative damage are major contributors to neuronal loss. Free radicals, typically generated from mitochondrial respiration, cause oxidative damage of nucleic acids, lipids, carbohydrates and proteins. Despite enormous amount of effort, however, the mechanism by which oxidative damage causes neuronal death is not well understood. Emerging data from a number of neurodegenerative diseases suggest that there may be common features of toxicity that are related to oxidative damage. In this review, while focusing on Huntington's disease (HD), we discuss similarities among HD, Friedreich ataxia and xeroderma pigmentosum, which provide insight into shared mechanisms of neuronal death.

Original languageEnglish (US)
Pages (from-to)1233-1248
Number of pages16
JournalNeuroscience
Volume145
Issue number4
DOIs
StatePublished - Apr 14 2007

Keywords

  • Friedreich ataxia
  • Huntington's disease
  • mitochondria
  • neurodegeneration
  • oxidative damage
  • xeroderma pigmentosum

ASJC Scopus subject areas

  • Neuroscience(all)

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