Oxidation-sensitive transcription factors and molecular mechanisms in the arterial wall

F. De Nigris, Lilach O Lerman, M. Condorelli, Amir Lerman, C. Napoli

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Adaptation to various forms of cellular stress involves signal transduction into the cytoplasm and subsequently into the cellular nucleus, and ultimately alteration of gene regulation and expression. Increased oxidative stress, which is associated with increased production of reactive oxygen species and other radical species, plays a pivotal role in vascular dysfunction and contributes substantially to the structural and functional changes leading to vascular disease progression. Activation of oxidation-sensitive transcription factors and molecular mechanisms can be triggered in the systemic, tissue, cellular, and molecular environments, thereby affecting a multitude of pathophysiological events involved in the pathogenesis of atherosclerosis and other vascular diseases. Radicals per se also participate in the pathophysiological vascular response to shear stress and injury. Among the oxidation-sensitive transcription factors, important roles have been ascribed to nuclear factor-κB, c-Myc, and the peroxisome proliferator-activated receptor family. Regulation of nuclear events has also been recently proposed to involve corepressor and coactivator molecules. Identification of the genes that are involved in these processes has been facilitated by recent development of microarray chip techniques, which allow simultaneous evaluation of differential gene expression. As many of the transcription factors or their interactions are redox-regulated, antioxidant intervention may affect their bioactivity.

Original languageEnglish (US)
Pages (from-to)1119-1130
Number of pages12
JournalAntioxidants and Redox Signaling
Volume3
Issue number6
StatePublished - 2001

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Gene expression
Transcription Factors
Vascular Diseases
Oxidation
Blood Vessels
Co-Repressor Proteins
Signal transduction
Peroxisome Proliferator-Activated Receptors
Oxidative stress
Gene Expression Regulation
Microarrays
Bioactivity
Oxidation-Reduction
Disease Progression
Shear stress
Reactive Oxygen Species
Signal Transduction
Atherosclerosis
Cytoplasm
Oxidative Stress

ASJC Scopus subject areas

  • Biochemistry

Cite this

Oxidation-sensitive transcription factors and molecular mechanisms in the arterial wall. / De Nigris, F.; Lerman, Lilach O; Condorelli, M.; Lerman, Amir; Napoli, C.

In: Antioxidants and Redox Signaling, Vol. 3, No. 6, 2001, p. 1119-1130.

Research output: Contribution to journalArticle

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