Ovine Corticotropin Releasing Hormone Stimulation Test: Normal Value Study

WILLIAM F. YOUNG, ALAN R. ZINSMEISTER, COLLEEN K. TWOMEY, PAI C. KAO, NAI SIANG JIANG, PAUL C. CARPENTER

Research output: Contribution to journalArticle

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Abstract

We determined the pituitary-adrenal response to 1 μg/kg of ovine corticotropin releasing hormone (oCRH) administered as an intravenous bolus injection in 50 normal subjects. Brief facial flushing was noted in 44% of the subjects; no other side effects were reported. Plasma corticotropin levels increased from a median of 30.2 pg/ml at baseline to a median peak level of 77.8 pg/ml after administration of oCRH; the peak response occurred at the 30- to 45-minute or the 45- to 60-minute time point. Plasma cortisol levels increased from a median of 10.8 μg/dl at baseline to a median peak level of 22.0 μg/dl after administration of oCRH; the peak response occurred at the 45- to 60-minute time point. Plasma β-endorphin levels increased from a median of 9.5 pg/ml at baseline to a median peak level of 23.0 pg/ml after administration of oCRH; the peak response occurred at the 15- to 30-minute or the 30- to 45-minute time point. The responsiveness to oCRH was unaffected by age, sex, or body mass index of the subjects.

Original languageEnglish (US)
Pages (from-to)943-948
Number of pages6
JournalMayo Clinic proceedings
Volume65
Issue number7
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Medicine(all)

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    YOUNG, WILLIAM. F., ZINSMEISTER, ALAN. R., TWOMEY, COLLEEN. K., KAO, PAI. C., JIANG, NAI. SIANG., & CARPENTER, PAUL. C. (1990). Ovine Corticotropin Releasing Hormone Stimulation Test: Normal Value Study. Mayo Clinic proceedings, 65(7), 943-948. https://doi.org/10.1016/S0025-6196(12)65155-6