Overview of Treatment Approaches for Fungal Infections

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided into 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, and pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

Original languageEnglish (US)
Pages (from-to)393-402
Number of pages10
JournalClinics in Chest Medicine
Volume38
Issue number3
DOIs
StatePublished - Sep 2017

Keywords

  • Amphotericin
  • Antifungal
  • Echinocandins
  • Flucytosine
  • Fungal infections
  • Invasive mycoses
  • Triazoles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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