Overview of Treatment Approaches for Fungal Infections

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14 Citations (Scopus)

Abstract

Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided in 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

Original languageEnglish (US)
JournalClinics in Chest Medicine
DOIs
StateAccepted/In press - 2017

Fingerprint

Echinocandins
Polyenes
Azoles
Mycoses
Antifungal Agents
Immunocompromised Host
Pharmacokinetics
Morbidity
Mortality
Infection
Pharmaceutical Preparations
Action Spectrum
pyrimidine

Keywords

  • Amphotericin
  • Antifungal
  • Echinocandins
  • Flucytosine
  • Fungal infections
  • Invasive mycoses
  • Triazoles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Overview of Treatment Approaches for Fungal Infections",
abstract = "Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided in 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.",
keywords = "Amphotericin, Antifungal, Echinocandins, Flucytosine, Fungal infections, Invasive mycoses, Triazoles",
author = "{Carmona Porquera}, {Eva M} and Limper, {Andrew Harold}",
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AU - Carmona Porquera, Eva M

AU - Limper, Andrew Harold

PY - 2017

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N2 - Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided in 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

AB - Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided in 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.

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KW - Echinocandins

KW - Flucytosine

KW - Fungal infections

KW - Invasive mycoses

KW - Triazoles

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