Overview of the genetics of parkinsonism

Mathias Toft, Zbigniew K Wszolek

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

During the last century, a large number of environmental factors were proposed as risk factors for the development of Parkinson’s disease (PD). Nevertheless, most epidemiological studies have been inconclusive, and the etiology of PD has remained largely unknown (Lees et al. 2009). Second to increasing age, a family history of PD is the strongest risk factor for the development of disease (Sellbach et al. 2006). PD is clinically defined as a syndrome with variable combinations of bradykinesia, rigidity, tremor, and postural instability (Lees et al. 2009). Pathologically, PD has traditionally been characterized as a disease with degeneration of dopaminergic neurons of the substantia nigra combined with the presence of Lewy bodies and cytoplasmic eosinophilic inclusions in surviving dopaminergic neurons and in other parts of the brain (Dickson et al. 2009).

Original languageEnglish (US)
Title of host publicationParkinson's Disease, Second Edition
PublisherCRC Press
Pages117-129
Number of pages13
ISBN (Electronic)9781439807156
ISBN (Print)9781439807149
DOIs
StatePublished - Jan 1 2012

Fingerprint

Parkinsonian Disorders
Parkinson Disease
Dopaminergic Neurons
Lewy Bodies
Hypokinesia
Inclusion Bodies
Tremor
Substantia Nigra
Epidemiologic Studies
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Toft, M., & Wszolek, Z. K. (2012). Overview of the genetics of parkinsonism. In Parkinson's Disease, Second Edition (pp. 117-129). CRC Press. https://doi.org/10.1201/b12948

Overview of the genetics of parkinsonism. / Toft, Mathias; Wszolek, Zbigniew K.

Parkinson's Disease, Second Edition. CRC Press, 2012. p. 117-129.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toft, M & Wszolek, ZK 2012, Overview of the genetics of parkinsonism. in Parkinson's Disease, Second Edition. CRC Press, pp. 117-129. https://doi.org/10.1201/b12948
Toft M, Wszolek ZK. Overview of the genetics of parkinsonism. In Parkinson's Disease, Second Edition. CRC Press. 2012. p. 117-129 https://doi.org/10.1201/b12948
Toft, Mathias ; Wszolek, Zbigniew K. / Overview of the genetics of parkinsonism. Parkinson's Disease, Second Edition. CRC Press, 2012. pp. 117-129
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