TY - JOUR
T1 - Overview of Lymphedema for Physicians and Other Clinicians
T2 - A Review of Fundamental Concepts
AU - Manrique, Oscar J.
AU - Bustos, Samyd S.
AU - Ciudad, Pedro
AU - Adabi, Kian
AU - Chen, Wei F.
AU - Forte, Antonio J.
AU - Cheville, Andrea L.
AU - Jakub, James W.
AU - McLaughlin, Sarah A.
AU - Chen, Hung Chi
N1 - Publisher Copyright:
© 2020 Mayo Foundation for Medical Education and Research
PY - 2022/10
Y1 - 2022/10
N2 - Lymphedema has historically been underrated in clinical practice, education, and scholarship to the detriment of many patients with this chronic, debilitating condition. The mechanical insufficiency of the lymphatic system causes the abnormal accumulation of protein-rich fluid in the interstitium, which triggers a cascade of adverse consequences such as fat deposition and fibrosis. As the condition progresses, patients present with extremity heaviness, itchiness, skin infections, and, in later stages, dermal fibrosis, skin papillomas, acanthosis, and other trophic skin changes. Correspondingly, lymphedema results in psychological morbidity, including anxiety, depression, social avoidance, and a decreased quality of life, encompassing emotional, functional, physical, and social domains. For this review, we conducted a literature search using PubMed and EMBASE and herein summarize the evidence related to the fundamental concepts of lymphedema. This article aims to raise awareness of this serious condition and outline and review the fundamental concepts of lymphedema.
AB - Lymphedema has historically been underrated in clinical practice, education, and scholarship to the detriment of many patients with this chronic, debilitating condition. The mechanical insufficiency of the lymphatic system causes the abnormal accumulation of protein-rich fluid in the interstitium, which triggers a cascade of adverse consequences such as fat deposition and fibrosis. As the condition progresses, patients present with extremity heaviness, itchiness, skin infections, and, in later stages, dermal fibrosis, skin papillomas, acanthosis, and other trophic skin changes. Correspondingly, lymphedema results in psychological morbidity, including anxiety, depression, social avoidance, and a decreased quality of life, encompassing emotional, functional, physical, and social domains. For this review, we conducted a literature search using PubMed and EMBASE and herein summarize the evidence related to the fundamental concepts of lymphedema. This article aims to raise awareness of this serious condition and outline and review the fundamental concepts of lymphedema.
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U2 - 10.1016/j.mayocp.2020.01.006
DO - 10.1016/j.mayocp.2020.01.006
M3 - Review article
C2 - 32829905
AN - SCOPUS:85089604765
SN - 0025-6196
VL - 97
SP - 1920
EP - 1935
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 10
ER -