Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution

Ippeita Dan, Norinobu M. Watanabe, Eriko Kajikawa, Takafumi Ishida, Akhilesh Pandey, Akihiro Kusumi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Overlapping of genes, especially in an anti-parallel fashion, is quite rare in eukaryotic genomes. We have found a rare instance of exon overlapping involving CHRNE and MINK gene loci on chromosome 17 in humans. CHRNE codes for the ε subunit of the nicotinic acetylcholine receptor (AChRε) whereas MINK encodes a serine/threonine kinase belonging to the GCK family. To elucidate the evolutionary trail of this gene overlapping event, we examined the genomes of a number of primates and found that mutations in the polyadenylation signal of the CHRNE gene in early hominoids led to the overlap. Upon extending this analysis to genomes of other orders of placental mammals, we observed that the overlapping occurred at least three times independently during the course of mammalian evolution. Because CHRNE and MINK are differentially expressed, the potentially hazardous mutations responsible for the exon overlap seem to have escaped evolutionary pressures by differential temporo-spatial expression of the two genes.

Original languageEnglish (US)
Pages (from-to)2906-2910
Number of pages5
JournalNucleic acids research
Volume30
Issue number13
StatePublished - Jul 1 2002
Externally publishedYes

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Overlapping Genes
Genome
Exons
Genes
Chromosomes, Human, Pair 17
Polyadenylation
Mutation
Protein-Serine-Threonine Kinases
Nicotinic Receptors
Primates
Mammals
Gene Expression
Pressure

ASJC Scopus subject areas

  • Genetics

Cite this

Dan, I., Watanabe, N. M., Kajikawa, E., Ishida, T., Pandey, A., & Kusumi, A. (2002). Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. Nucleic acids research, 30(13), 2906-2910.

Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. / Dan, Ippeita; Watanabe, Norinobu M.; Kajikawa, Eriko; Ishida, Takafumi; Pandey, Akhilesh; Kusumi, Akihiro.

In: Nucleic acids research, Vol. 30, No. 13, 01.07.2002, p. 2906-2910.

Research output: Contribution to journalArticle

Dan, I, Watanabe, NM, Kajikawa, E, Ishida, T, Pandey, A & Kusumi, A 2002, 'Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution', Nucleic acids research, vol. 30, no. 13, pp. 2906-2910.
Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. Nucleic acids research. 2002 Jul 1;30(13):2906-2910.
Dan, Ippeita ; Watanabe, Norinobu M. ; Kajikawa, Eriko ; Ishida, Takafumi ; Pandey, Akhilesh ; Kusumi, Akihiro. / Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. In: Nucleic acids research. 2002 ; Vol. 30, No. 13. pp. 2906-2910.
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