Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: Prevalence and risk factors in the general population

H. K. Jung, S. Halder, M. McNally, G. R. Locke, C. D. Schleck, A. R. Zinsmeister, N. J. Talley

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Abstract

Background: Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown. Aim: To determine prevalence and risk factors for overlap of GERD and irritable bowel disease. Methods: Population-based, cross-sectional survey was conducted by mailing a valid symptom questionnaire to eligible residents of Olmsted County, MN, aged 30-95 years. Irritable bowel syndrome were defined by Rome III; GERD was defined by weekly or more frequent heartburn and/or acid regurgitation. Results: 2298 questionnaires returned (women 52%, 55% response). Irritable bowel syndrome and GERD occurred together more commonly than expected by chance; the prevalence of irritable bowel syndrome-GERD overlap, GERD alone and irritable bowel syndrome alone were 3%, 15% and 5% in men, and 4%, 14% and 10% in women, respectively. Predictors of irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone, and separately, GERD alone, were insomnia (OR 1.3, 95% CI: 1.06-1.70; OR 1.5, 95% CI: 1.13-1.90, respectively) and frequent abdominal pain (OR 3.9, 2.2-6.7; OR 1.8, 1.02-3.2, respectively). An additional predictor of irritable bowel syndrome-GERD overlap vs. GERD alone was higher somatization (OR 1.7, 1.1-2.4) and for irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone was a higher body mass index (OR 1.0, 1.003-1.07). Conclusions: Irritable bowel syndrome and GERD overlap is common in the population and does not occur by chance.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalAlimentary Pharmacology and Therapeutics
Volume26
Issue number3
DOIs
StatePublished - Aug 2007

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Esophageal Diseases
Irritable Bowel Syndrome
Gastroesophageal Reflux
Population
Heartburn
Sleep Initiation and Maintenance Disorders
Abdominal Pain

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome : Prevalence and risk factors in the general population. / Jung, H. K.; Halder, S.; McNally, M.; Locke, G. R.; Schleck, C. D.; Zinsmeister, A. R.; Talley, N. J.

In: Alimentary Pharmacology and Therapeutics, Vol. 26, No. 3, 08.2007, p. 453-461.

Research output: Contribution to journalArticle

Jung, H. K. ; Halder, S. ; McNally, M. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Talley, N. J. / Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome : Prevalence and risk factors in the general population. In: Alimentary Pharmacology and Therapeutics. 2007 ; Vol. 26, No. 3. pp. 453-461.
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AU - Jung, H. K.

AU - Halder, S.

AU - McNally, M.

AU - Locke, G. R.

AU - Schleck, C. D.

AU - Zinsmeister, A. R.

AU - Talley, N. J.

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N2 - Background: Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown. Aim: To determine prevalence and risk factors for overlap of GERD and irritable bowel disease. Methods: Population-based, cross-sectional survey was conducted by mailing a valid symptom questionnaire to eligible residents of Olmsted County, MN, aged 30-95 years. Irritable bowel syndrome were defined by Rome III; GERD was defined by weekly or more frequent heartburn and/or acid regurgitation. Results: 2298 questionnaires returned (women 52%, 55% response). Irritable bowel syndrome and GERD occurred together more commonly than expected by chance; the prevalence of irritable bowel syndrome-GERD overlap, GERD alone and irritable bowel syndrome alone were 3%, 15% and 5% in men, and 4%, 14% and 10% in women, respectively. Predictors of irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone, and separately, GERD alone, were insomnia (OR 1.3, 95% CI: 1.06-1.70; OR 1.5, 95% CI: 1.13-1.90, respectively) and frequent abdominal pain (OR 3.9, 2.2-6.7; OR 1.8, 1.02-3.2, respectively). An additional predictor of irritable bowel syndrome-GERD overlap vs. GERD alone was higher somatization (OR 1.7, 1.1-2.4) and for irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone was a higher body mass index (OR 1.0, 1.003-1.07). Conclusions: Irritable bowel syndrome and GERD overlap is common in the population and does not occur by chance.

AB - Background: Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown. Aim: To determine prevalence and risk factors for overlap of GERD and irritable bowel disease. Methods: Population-based, cross-sectional survey was conducted by mailing a valid symptom questionnaire to eligible residents of Olmsted County, MN, aged 30-95 years. Irritable bowel syndrome were defined by Rome III; GERD was defined by weekly or more frequent heartburn and/or acid regurgitation. Results: 2298 questionnaires returned (women 52%, 55% response). Irritable bowel syndrome and GERD occurred together more commonly than expected by chance; the prevalence of irritable bowel syndrome-GERD overlap, GERD alone and irritable bowel syndrome alone were 3%, 15% and 5% in men, and 4%, 14% and 10% in women, respectively. Predictors of irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone, and separately, GERD alone, were insomnia (OR 1.3, 95% CI: 1.06-1.70; OR 1.5, 95% CI: 1.13-1.90, respectively) and frequent abdominal pain (OR 3.9, 2.2-6.7; OR 1.8, 1.02-3.2, respectively). An additional predictor of irritable bowel syndrome-GERD overlap vs. GERD alone was higher somatization (OR 1.7, 1.1-2.4) and for irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone was a higher body mass index (OR 1.0, 1.003-1.07). Conclusions: Irritable bowel syndrome and GERD overlap is common in the population and does not occur by chance.

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