Overlap of dyspepsia and gastroesophageal reflux in the general population: One disease or distinct entities?

R. S. Choung, G. R. Locke, C. D. Schleck, A. R. Zinsmeister, N. J. Talley

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume24
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Dyspepsia
Gastroesophageal Reflux
Population
Heartburn
Proton Pump Inhibitors
Sleep Initiation and Maintenance Disorders
Checklist

Keywords

  • Dyspepsia
  • Gastroesophageal reflux
  • Population-based study

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Overlap of dyspepsia and gastroesophageal reflux in the general population : One disease or distinct entities? / Choung, R. S.; Locke, G. R.; Schleck, C. D.; Zinsmeister, A. R.; Talley, N. J.

In: Neurogastroenterology and Motility, Vol. 24, No. 3, 03.2012.

Research output: Contribution to journalArticle

Choung, R. S. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Talley, N. J. / Overlap of dyspepsia and gastroesophageal reflux in the general population : One disease or distinct entities?. In: Neurogastroenterology and Motility. 2012 ; Vol. 24, No. 3.
@article{0477e73415d346d996201e3850d5fd1c,
title = "Overlap of dyspepsia and gastroesophageal reflux in the general population: One disease or distinct entities?",
abstract = "Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48{\%}). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.",
keywords = "Dyspepsia, Gastroesophageal reflux, Population-based study",
author = "Choung, {R. S.} and Locke, {G. R.} and Schleck, {C. D.} and Zinsmeister, {A. R.} and Talley, {N. J.}",
year = "2012",
month = "3",
doi = "10.1111/j.1365-2982.2011.01845.x",
language = "English (US)",
volume = "24",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Overlap of dyspepsia and gastroesophageal reflux in the general population

T2 - One disease or distinct entities?

AU - Choung, R. S.

AU - Locke, G. R.

AU - Schleck, C. D.

AU - Zinsmeister, A. R.

AU - Talley, N. J.

PY - 2012/3

Y1 - 2012/3

N2 - Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.

AB - Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.

KW - Dyspepsia

KW - Gastroesophageal reflux

KW - Population-based study

UR - http://www.scopus.com/inward/record.url?scp=84856767906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856767906&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2982.2011.01845.x

DO - 10.1111/j.1365-2982.2011.01845.x

M3 - Article

C2 - 22150874

AN - SCOPUS:84856767906

VL - 24

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 3

ER -