TY - JOUR
T1 - Overlap of dyspepsia and gastroesophageal reflux in the general population
T2 - One disease or distinct entities?
AU - Choung, R. S.
AU - Locke, G. R.
AU - Schleck, C. D.
AU - Zinsmeister, A. R.
AU - Talley, N. J.
PY - 2012/3
Y1 - 2012/3
N2 - Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.
AB - Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap. Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation. Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR=1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR=1.4 (1.1, 1.7), OR=1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR=2.4 (1.5, 3.8)]. Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.
KW - Dyspepsia
KW - Gastroesophageal reflux
KW - Population-based study
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U2 - 10.1111/j.1365-2982.2011.01845.x
DO - 10.1111/j.1365-2982.2011.01845.x
M3 - Article
C2 - 22150874
AN - SCOPUS:84856767906
SN - 1350-1925
VL - 24
SP - 229-e106
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 3
ER -