Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.

Javier A. Menendez, Santiago Ropero, Inderjit Mehmi, Ella Atlas, Ramon Colomer, Ruth Lupu

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Medicine & Life Sciences