Overcoming obstacles in the design of cancer anorexia/weight loss trials

Jennifer Le-Rademacher, Jeffrey Crawford, William J. Evans, Aminah Jatoi

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Most advanced cancer patients suffer loss of appetite (anorexia) and loss of weight. Despite the fact that cancer anorexia and weight loss are associated with a poor prognosis and detract from quality of life, no interventions have been demonstrated to palliate this syndrome in its entirety, particularly in patients with treatment-refractory malignancies. Recently, two registration trials − one with anamorelin and another with enobosarm − failed to reach their primary endpoints, thus raising questions. Were both these agents ineffective? Alternatively, did study design issues compromise the ability of these trials to identify effective agents? Thus, this review is timely insofar it serves as an introduction to study design, offers guidance on how to test promising agents for cancer anorexia/weight loss, and provides advice for overcoming trial design obstacles.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume117
DOIs
StatePublished - Sep 1 2017

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Keywords

  • Anorexia
  • Cancer
  • Study design
  • Weight loss

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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