Ovarian cancer in the United States: Contemporary patterns of care associated with improved survival

William A. Cliby, Matthew A. Powell, Noor Al-Hammadi, Ling Chen, J. Philip Miller, Phillip Y. Roland, David G. Mutch, Robert E. Bristow

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Background. Ovarian cancer (OC) requires complex multidisciplinary care with wide variations in outcome. We sought to determine the impact of institutional and process of care factors on overall survival (OS) and delivery of guideline care nationally. Methods. This was a retrospective cohort study of primary OC diagnosed from 1998 to 2007 using the National Cancer Data Base (NCDB) capturing 80% of all U.S. cases. Patient- (demographics, comorbidities, stage/grade), process of care (adherence to guidelines) and institutional- (facility type, case volume) factors were evaluated. Primary outcomes were OS and delivery of guideline therapy. Multivariable logistic regression and Cox proportional hazards models were used for analysis. Results. We analyzed 96,802 consecutive cases. Five-year OS was 84%, 66.3%, 32% and 15.7% for stages I, II, III and IV, respectively. The annual mean facility case volumes varied by cancer center type (range: 5.7 to 26.7), with 25% of cases spread over 65% of centers - all treating fewer than 8 cases. Overall, 56% of cases received nonguideline care. Low facility case volume and higher comorbidity index independently predicted non-guideline care; high volume centers were less likely to deliver non-guideline care (OR: 0.44, 95% CI: 0.41-0.47). Delivery of non-guideline care (OR: 1.4, 95% CI: 1.36-1.44), and higher facility case volume (OR: 0.91, 95% CI: 0.86- 0.96) were both independent predictors of OS. Conclusions. Delivery of guideline care and facility case volume are important drivers of overall survival. Most cancer centers treat very few women with OC. National efforts should focus on improved access to centers with expertise in OC and ensuring delivery of guideline care.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalGynecologic oncology
Volume136
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Cancer center
  • Care patterns
  • Ovarian cancer
  • Survival
  • United states
  • Volume

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Ovarian cancer in the United States: Contemporary patterns of care associated with improved survival'. Together they form a unique fingerprint.

  • Cite this

    Cliby, W. A., Powell, M. A., Al-Hammadi, N., Chen, L., Miller, J. P., Roland, P. Y., Mutch, D. G., & Bristow, R. E. (2015). Ovarian cancer in the United States: Contemporary patterns of care associated with improved survival. Gynecologic oncology, 136(1), 11-17. https://doi.org/10.1016/j.ygyno.2014.10.023