"Outer-directed irritability": A distinct mood syndrome in explosive youth with a disruptive behavior disorder?

Stephen J. Donovan, Edward V. Nunes, Jonathan W. Stewart, Don Ross, Frederic M. Quitkin, Peter S. Jensen, Donald F. Klein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To examine whether "outer-directed irritability," a mood construct from the adult literature, characterizes a subgroup of disruptive behavior disordered children and adolescents previously shown to improve on divalproex, a mood stabilizer. Method: A sample (N = 20) of disruptive youth (aged 10-18 years) entering a divalproex treatment study of temper and irritable mood swings was compared to normal controls (N = 18) on measures of aggression/irritability directed against others (externalizing symptoms) and on aggression/irritability against self, anxiety, and depression (internalizing symptoms). All patients met DSM-IV criteria for a disruptive behavior disorder (oppositional defiant disorder of conduct disorder) in addition to research criteria. Results: "Outer-directed irritability" most clearly distinguished patients from controls (effect size 4.1) and did not correlate with other mood measures. Patients and controls showed no to minimal differences on internalizing symptoms. Conclusion: Disruptive behavior disordered children and adolescents characterized by outer-directed irritability exist, can be identified, and should be further investigated, especially since they are potentially treatable.

Original languageEnglish (US)
Pages (from-to)698-701
Number of pages4
JournalJournal of Clinical Psychiatry
Volume64
Issue number6
StatePublished - Jun 1 2003
Externally publishedYes

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Attention Deficit and Disruptive Behavior Disorders
Valproic Acid
Aggression
Irritable Mood
Conduct Disorder
Diagnostic and Statistical Manual of Mental Disorders
Anxiety
Depression
Research
Problem Behavior
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Donovan, S. J., Nunes, E. V., Stewart, J. W., Ross, D., Quitkin, F. M., Jensen, P. S., & Klein, D. F. (2003). "Outer-directed irritability": A distinct mood syndrome in explosive youth with a disruptive behavior disorder? Journal of Clinical Psychiatry, 64(6), 698-701.

"Outer-directed irritability" : A distinct mood syndrome in explosive youth with a disruptive behavior disorder? / Donovan, Stephen J.; Nunes, Edward V.; Stewart, Jonathan W.; Ross, Don; Quitkin, Frederic M.; Jensen, Peter S.; Klein, Donald F.

In: Journal of Clinical Psychiatry, Vol. 64, No. 6, 01.06.2003, p. 698-701.

Research output: Contribution to journalArticle

Donovan, SJ, Nunes, EV, Stewart, JW, Ross, D, Quitkin, FM, Jensen, PS & Klein, DF 2003, '"Outer-directed irritability": A distinct mood syndrome in explosive youth with a disruptive behavior disorder?', Journal of Clinical Psychiatry, vol. 64, no. 6, pp. 698-701.
Donovan SJ, Nunes EV, Stewart JW, Ross D, Quitkin FM, Jensen PS et al. "Outer-directed irritability": A distinct mood syndrome in explosive youth with a disruptive behavior disorder? Journal of Clinical Psychiatry. 2003 Jun 1;64(6):698-701.
Donovan, Stephen J. ; Nunes, Edward V. ; Stewart, Jonathan W. ; Ross, Don ; Quitkin, Frederic M. ; Jensen, Peter S. ; Klein, Donald F. / "Outer-directed irritability" : A distinct mood syndrome in explosive youth with a disruptive behavior disorder?. In: Journal of Clinical Psychiatry. 2003 ; Vol. 64, No. 6. pp. 698-701.
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