Outcomes of Patients With Severe Chronic Lung Disease Who Are Undergoing Transcatheter Aortic Valve Replacement

Rakesh M. Suri, Brian C. Gulack, J. Matthew Brennan, Vinod H. Thourani, Dadi Dai, Alan Zajarias, Kevin L. Greason, Christina M. Vassileva, Verghese Mathew, Vuyisile T Nkomo, Michael J. Mack, Charanjit Rihal, Lars G. Svensson, Rick A. Nishimura, Patrick T. O'Gara, David Holmes

Research output: Contribution to journalArticle

27 Scopus citations


Background: In this study, we sought to determine the clinical outcomes after transcatheter aortic valve replacement (TAVR) among patients with chronic lung disease (CLD) and to evaluate the safety of transaortic versus transapical alternate access approaches in patients with varying severities of CLD. Methods: Clinical records for patients undergoing TAVR from 2011 to 2014 in The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry were linked to Medicare hospital claims (n= 11,656). Clinical outcomes were evaluated across strata of CLD severity, and the risk-adjusted association between access route and post-TAVR mortality was determined among patients with severe CLD. Results: In this cohort (median age, 84 years; 51.7% female), moderate to severe CLD was present in 27.7% (14.3%, moderate; 13.4%, severe). Compared with patients with no or mild CLD, patients with severe CLD had a higher rate of post-TAVR mortality to 1-year (32.3% versus 21.0%; adjusted hazard ratio [HR], 1.48; 95% confidence interval [CI], 1.31 to 1.66), as did those with moderate CLD (25.5%; adjusted HR, 1.16; 95% CI, 1.03 to 1.30). The adjusted rate of mortality was similar for transapical versus transaortic approaches to 1 year (adjusted HR, 1.17; 95% CI, 0.83 to 1.65). Conclusions: Moderate or severe CLD is associated with an increased risk of death to 1-year after TAVR, andamong patients with severe CLD, the risk of deathappears to be similar with either transapical or transaortic alternate-access approaches. Further study is necessary to understand strategies to mitigate risk associated with CLD and the long-term implications of these findings.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
StateAccepted/In press - 2015


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Suri, R. M., Gulack, B. C., Brennan, J. M., Thourani, V. H., Dai, D., Zajarias, A., Greason, K. L., Vassileva, C. M., Mathew, V., Nkomo, V. T., Mack, M. J., Rihal, C., Svensson, L. G., Nishimura, R. A., O'Gara, P. T., & Holmes, D. (Accepted/In press). Outcomes of Patients With Severe Chronic Lung Disease Who Are Undergoing Transcatheter Aortic Valve Replacement. Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2015.05.075