Outcomes of patients with POEMS syndrome treated initially with radiation

Michael S. Humeniuk, Morie Gertz, Martha Lacy, Robert A. Kyle, Thomas Elmer Witzig, Shaji K Kumar, Prashant Kapoor, John A. Lust, Suzanne R. Hayman, Francis K. Buadi, S Vincent Rajkumar, Steven R. Zeldenrust, Stephen J Russell, David M Dingli, Yi Lin, Nelson Leung, Angela Dispenzieri

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

POEMS syndrome is a rare plasma cell dyscrasia presenting with polyneuropathy and other systemic findings. Patients with 1 to 3 bone lesions and negative bone marrows are often treated with involved field radiation therapy as the initial and potentially definitive therapy. Long-term outcomes of patients treated with this approach have not been systematically studied. Of the 146 patients with POEMS syndrome seen at the Mayo Clinic between January 1999 and September 2011, 38 (26%) were given targeted radiation as their initial primary therapy and are the ones studied here. The median number of bone lesions was 1 (range: 1-6). Themedian dose of radiation administered was 45 Gy (range: 35-54 Gy). Complete or partial hematologic, vascular endothelial growth factor, fluorodeoxyglucose-positronemission tomography, and clinical responses were documented in 31%, 14%, 22%, and 47%, respectively. Withmedian followup of 43 months, the 4-year overall survival is 97% and event-free survival is 52%. Risk factors for needing salvage therapy included reduced pulmonary diffusing capacity of carbon monoxide and increased urinary total protein. The presence of 3 lesions compared with 1 or 2 did not increase risk for treatment failure. Among selected patients with POEMS syndrome, radiation produces durable, meaningful responses.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalBlood
Volume122
Issue number1
DOIs
StatePublished - Jul 4 2013

Fingerprint

POEMS Syndrome
Bone
Radiation
Salvaging
Pulmonary Diffusing Capacity
Radiotherapy
Carbon Monoxide
Bone and Bones
Salvage Therapy
Vascular Endothelial Growth Factor A
Paraproteinemias
Dosimetry
Tomography
Polyneuropathies
Treatment Failure
Disease-Free Survival
Plasmas
Bone Marrow
Survival
Proteins

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Outcomes of patients with POEMS syndrome treated initially with radiation. / Humeniuk, Michael S.; Gertz, Morie; Lacy, Martha; Kyle, Robert A.; Witzig, Thomas Elmer; Kumar, Shaji K; Kapoor, Prashant; Lust, John A.; Hayman, Suzanne R.; Buadi, Francis K.; Rajkumar, S Vincent; Zeldenrust, Steven R.; Russell, Stephen J; Dingli, David M; Lin, Yi; Leung, Nelson; Dispenzieri, Angela.

In: Blood, Vol. 122, No. 1, 04.07.2013, p. 68-73.

Research output: Contribution to journalArticle

Humeniuk, Michael S. ; Gertz, Morie ; Lacy, Martha ; Kyle, Robert A. ; Witzig, Thomas Elmer ; Kumar, Shaji K ; Kapoor, Prashant ; Lust, John A. ; Hayman, Suzanne R. ; Buadi, Francis K. ; Rajkumar, S Vincent ; Zeldenrust, Steven R. ; Russell, Stephen J ; Dingli, David M ; Lin, Yi ; Leung, Nelson ; Dispenzieri, Angela. / Outcomes of patients with POEMS syndrome treated initially with radiation. In: Blood. 2013 ; Vol. 122, No. 1. pp. 68-73.
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