Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704

Soham D. Puvvada, Patrick J. Stiff, Michael Leblanc, James R. Cook, Stephen Couban, John P. Leonard, Brad Kahl, Deborah Marcellus, Thomas C. Shea, Jane N. Winter, Hongli Li, Lisa M. Rimsza, Jonathan W. Friedberg, Sonali M. Smith

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/−R with or without ASCT enabled evaluation of intensive consolidation. Immunohistochemistry (IHC) identified 27 of 198 patients (13·6%) with MYC overexpression; 20 (74%) harboured concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median 127 months follow-up, there is a trend favouring outcomes after ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT.

Original languageEnglish (US)
Pages (from-to)686-691
Number of pages6
JournalBritish journal of haematology
Volume174
Issue number5
DOIs
StatePublished - Sep 1 2016

Keywords

  • BCL2
  • MYC
  • autologous stem cell transplant
  • double hit lymphoma
  • double protein lymphoma

ASJC Scopus subject areas

  • Hematology

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    Puvvada, S. D., Stiff, P. J., Leblanc, M., Cook, J. R., Couban, S., Leonard, J. P., Kahl, B., Marcellus, D., Shea, T. C., Winter, J. N., Li, H., Rimsza, L. M., Friedberg, J. W., & Smith, S. M. (2016). Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704. British journal of haematology, 174(5), 686-691. https://doi.org/10.1111/bjh.14100