Outcomes of definitive chemoradiation in patients with esophageal cancer

Sameh Mikhail, Lai Wei, Mohamed E. Salem, Tanios Bekaii-Saab

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The incidence of esophageal cancer has risen dramatically in the Western world. Although surgical resection of esophageal tumors is considered the cornerstone of curative approaches in localized esophageal cancer, approximately 40% of patients who undergo chemoradiation followed by surgery will experience a recurrence. Additionally, surgical resection is not a viable option for many patients with locally advanced unresectable disease, poor general condition or whose condition deteriorated following chemoradiation. Several investigators have, therefore, attempted to evaluate the outcomes of definitive chemoradiation in patients with localized or locally advanced esophageal cancer. The outcomes of concurrent chemoradiation remain a matter of debate given the heterogenous study design and treatment regimens used in recent trials. Understanding the clinical benefit of chemoradiation is essential prior to recommending it as an alternative to surgery. In our review, we present the most recent studies evaluating the role of chemoradiation to better define the clinical outcomes of patients with special attention to overall survival.

Original languageEnglish (US)
Article number12506
JournalDiseases of the Esophagus
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Chemoradiation
  • Esophageal cancer
  • Esophagectomy
  • Outcomes
  • Survival

ASJC Scopus subject areas

  • Gastroenterology

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