Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo; James R. Cerhan; Elliot J. Cahn; Philippe R. Bauer; Zelalem Temesgen; Jon Ebbert; Andy Abril; Omar M. Abu Saleh; Mariam Assi; Elie F. Berbari; Dennis M. Bierle; Wendelyn Bosch; Charles D. Burger; Edison J. Cano Cevallos; Casey M. Clements; Eva M. Carmona Porquera; Natalia E. Castillo Almeida; Douglas W. Challener; Supavit Chesdachai; Isin Y. Comba; Cristina G. Corsini Campioli; Sarah J. Crane; Ala S. Dababneh; Mark J. Enzler; Hind J. Fadel; Ravindra Ganesh; Alice Gallo De Moraes; John R. Go; Joel E. Gordon; Pooja R. Gurram; Pramod K. Guru; Erika L. Halverson; Michael F. Harrison; Heather A. Heaton; Ryan Hurt; Mary J. Kasten; Augustine S. Lee; Emily R. Levy; Claudia R. Libertin; Jorge M. Mallea; William F. Marshall; Gautam Matcha; Anne M. Meehan; Pablo Moreno Franco; William G. Morice; Jennifer J. O'Brien; Richard Oeckler; Steve Ommen; Caitlin P. Oravec; Robert Orenstein; Natalie J. Ough; Raj Palraj; Bhavesh M. Patel; Vincent S. Pureza; Brian Pickering; David M. Phelan; Raymund R. Razonable; Stacey Rizza; Priya Sampathkumar; Devang K. Sanghavi; Ayan Sen; Jason L. Siegel; Kai Singbartl; Aditya S. Shah; F. N.U. Shweta; Leigh L. Speicher; Gina Suh; Hussam Tabaja; Aaron Tande; Henry H. Ting; Russell C. Tontz; James J. Vaillant; Paschalis Vergidis; Mohamed Y. Warsame; Zachary A. Yetmar; Catherine (Cate) D. Zomok; Amy W. Williams; Andrew D. Badley

doi:10.1016/j.mayocp.2020.12.006

Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo, James R. Cerhan, Elliot J. Cahn, Philippe R. Bauer, Zelalem Temesgen, Jon Ebbert, Andy Abril, Omar M. Abu Saleh, Mariam Assi, Elie F. Berbari, Dennis M. Bierle, Wendelyn Bosch, Charles D. Burger, Edison J. Cano Cevallos, Casey M. Clements, Eva M. Carmona Porquera, Natalia E. Castillo Almeida, Douglas W. Challener, Supavit Chesdachai, Isin Y. CombaCristina G. Corsini Campioli, Sarah J. Crane, Ala S. Dababneh, Mark J. Enzler, Hind J. Fadel, Ravindra Ganesh, Alice Gallo De Moraes, John R. Go, Joel E. Gordon, Pooja R. Gurram, Pramod K. Guru, Erika L. Halverson, Michael F. Harrison, Heather A. Heaton, Ryan Hurt, Mary J. Kasten, Augustine S. Lee, Emily R. Levy, Claudia R. Libertin, Jorge M. Mallea, William F. Marshall, Gautam Matcha, Anne M. Meehan, Pablo Moreno Franco, William G. Morice, Jennifer J. O'Brien, Richard Oeckler, Steve Ommen, Caitlin P. Oravec, Robert Orenstein, Natalie J. Ough, Raj Palraj, Bhavesh M. Patel, Vincent S. Pureza, Brian Pickering, David M. Phelan, Raymund R. Razonable, Stacey Rizza, Priya Sampathkumar, Devang K. Sanghavi, Ayan Sen, Jason L. Siegel, Kai Singbartl, Aditya S. Shah, F. N.U. Shweta, Leigh L. Speicher, Gina Suh, Hussam Tabaja, Aaron Tande, Henry H. Ting, Russell C. Tontz, James J. Vaillant, Paschalis Vergidis, Mohamed Y. Warsame, Zachary A. Yetmar, Catherine (Cate) D. Zomok, Amy W. Williams, Andrew D. Badley

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes. Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models. Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19–directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care. Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic.

Original language	English (US)
Pages (from-to)	601-618
Number of pages	18
Journal	Mayo Clinic proceedings
Volume	96
Issue number	3
DOIs	https://doi.org/10.1016/j.mayocp.2020.12.006
State	Published - Mar 2021

ASJC Scopus subject areas

General Medicine

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10.1016/j.mayocp.2020.12.006

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O'Horo, J. C., Cerhan, J. R., Cahn, E. J., Bauer, P. R., Temesgen, Z., Ebbert, J., Abril, A., Abu Saleh, O. M., Assi, M., Berbari, E. F., Bierle, D. M., Bosch, W., Burger, C. D., Cano Cevallos, E. J., Clements, C. M., Carmona Porquera, E. M., Castillo Almeida, N. E., Challener, D. W., Chesdachai, S., ... Badley, A. D. (2021). Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research. Mayo Clinic proceedings, 96(3), 601-618. https://doi.org/10.1016/j.mayocp.2020.12.006

O'Horo, JC, Cerhan, JR, Cahn, EJ, Bauer, PR, Temesgen, Z , Ebbert, J, Abril, A, Abu Saleh, OM, Assi, M, Berbari, EF, Bierle, DM, Bosch, W, Burger, CD, Cano Cevallos, EJ, Clements, CM, Carmona Porquera, EM, Castillo Almeida, NE, Challener, DW, Chesdachai, S, Comba, IY, Corsini Campioli, CG, Crane, SJ, Dababneh, AS, Enzler, MJ, Fadel, HJ, Ganesh, R, De Moraes, AG, Go, JR, Gordon, JE, Gurram, PR, Guru, PK, Halverson, EL, Harrison, MF, Heaton, HA, Hurt, R, Kasten, MJ, Lee, AS, Levy, ER, Libertin, CR, Mallea, JM, Marshall, WF, Matcha, G, Meehan, AM, Franco, PM, Morice, WG, O'Brien, JJ, Oeckler, R, Ommen, S, Oravec, CP, Orenstein, R, Ough, NJ, Palraj, R, Patel, BM, Pureza, VS, Pickering, B, Phelan, DM, Razonable, RR , Rizza, S, Sampathkumar, P, Sanghavi, DK, Sen, A, Siegel, JL, Singbartl, K, Shah, AS, Shweta, FNU, Speicher, LL, Suh, G, Tabaja, H, Tande, A, Ting, HH, Tontz, RC, Vaillant, JJ, Vergidis, P, Warsame, MY, Yetmar, ZA, Zomok, CD, Williams, AW & Badley, AD 2021, 'Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research', Mayo Clinic proceedings, vol. 96, no. 3, pp. 601-618. https://doi.org/10.1016/j.mayocp.2020.12.006

@article{2ca427a98dc441f0ba731cac28d8e569,

title = "Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research",

abstract = "Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes. Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models. Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19–directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care. Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic.",

author = "O'Horo, {John Charles} and Cerhan, {James R.} and Cahn, {Elliot J.} and Bauer, {Philippe R.} and Zelalem Temesgen and Jon Ebbert and Andy Abril and {Abu Saleh}, {Omar M.} and Mariam Assi and Berbari, {Elie F.} and Bierle, {Dennis M.} and Wendelyn Bosch and Burger, {Charles D.} and {Cano Cevallos}, {Edison J.} and Clements, {Casey M.} and {Carmona Porquera}, {Eva M.} and {Castillo Almeida}, {Natalia E.} and Challener, {Douglas W.} and Supavit Chesdachai and Comba, {Isin Y.} and {Corsini Campioli}, {Cristina G.} and Crane, {Sarah J.} and Dababneh, {Ala S.} and Enzler, {Mark J.} and Fadel, {Hind J.} and Ravindra Ganesh and {De Moraes}, {Alice Gallo} and Go, {John R.} and Gordon, {Joel E.} and Gurram, {Pooja R.} and Guru, {Pramod K.} and Halverson, {Erika L.} and Harrison, {Michael F.} and Heaton, {Heather A.} and Ryan Hurt and Kasten, {Mary J.} and Lee, {Augustine S.} and Levy, {Emily R.} and Libertin, {Claudia R.} and Mallea, {Jorge M.} and Marshall, {William F.} and Gautam Matcha and Meehan, {Anne M.} and Franco, {Pablo Moreno} and Morice, {William G.} and O'Brien, {Jennifer J.} and Richard Oeckler and Steve Ommen and Oravec, {Caitlin P.} and Robert Orenstein and Ough, {Natalie J.} and Raj Palraj and Patel, {Bhavesh M.} and Pureza, {Vincent S.} and Brian Pickering and Phelan, {David M.} and Razonable, {Raymund R.} and Stacey Rizza and Priya Sampathkumar and Sanghavi, {Devang K.} and Ayan Sen and Siegel, {Jason L.} and Kai Singbartl and Shah, {Aditya S.} and Shweta, {F. N.U.} and Speicher, {Leigh L.} and Gina Suh and Hussam Tabaja and Aaron Tande and Ting, {Henry H.} and Tontz, {Russell C.} and Vaillant, {James J.} and Paschalis Vergidis and Warsame, {Mohamed Y.} and Yetmar, {Zachary A.} and Zomok, {Catherine (Cate) D.} and Williams, {Amy W.} and Badley, {Andrew D.}",

note = "Publisher Copyright: {\textcopyright} 2020 Mayo Foundation for Medical Education and Research",

year = "2021",

month = mar,

doi = "10.1016/j.mayocp.2020.12.006",

language = "English (US)",

volume = "96",

pages = "601--618",

journal = "Mayo Clinic proceedings",

issn = "0025-6196",

publisher = "Elsevier Science",

number = "3",

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TY - JOUR

T1 - Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

AU - O'Horo, John Charles

AU - Cerhan, James R.

AU - Cahn, Elliot J.

AU - Bauer, Philippe R.

AU - Temesgen, Zelalem

AU - Ebbert, Jon

AU - Abril, Andy

AU - Abu Saleh, Omar M.

AU - Assi, Mariam

AU - Berbari, Elie F.

AU - Bierle, Dennis M.

AU - Bosch, Wendelyn

AU - Burger, Charles D.

AU - Cano Cevallos, Edison J.

AU - Clements, Casey M.

AU - Carmona Porquera, Eva M.

AU - Castillo Almeida, Natalia E.

AU - Challener, Douglas W.

AU - Chesdachai, Supavit

AU - Comba, Isin Y.

AU - Corsini Campioli, Cristina G.

AU - Crane, Sarah J.

AU - Dababneh, Ala S.

AU - Enzler, Mark J.

AU - Fadel, Hind J.

AU - Ganesh, Ravindra

AU - De Moraes, Alice Gallo

AU - Go, John R.

AU - Gordon, Joel E.

AU - Gurram, Pooja R.

AU - Guru, Pramod K.

AU - Halverson, Erika L.

AU - Harrison, Michael F.

AU - Heaton, Heather A.

AU - Hurt, Ryan

AU - Kasten, Mary J.

AU - Lee, Augustine S.

AU - Levy, Emily R.

AU - Libertin, Claudia R.

AU - Mallea, Jorge M.

AU - Marshall, William F.

AU - Matcha, Gautam

AU - Meehan, Anne M.

AU - Franco, Pablo Moreno

AU - Morice, William G.

AU - O'Brien, Jennifer J.

AU - Oeckler, Richard

AU - Ommen, Steve

AU - Oravec, Caitlin P.

AU - Orenstein, Robert

AU - Ough, Natalie J.

AU - Palraj, Raj

AU - Patel, Bhavesh M.

AU - Pureza, Vincent S.

AU - Pickering, Brian

AU - Phelan, David M.

AU - Razonable, Raymund R.

AU - Rizza, Stacey

AU - Sampathkumar, Priya

AU - Sanghavi, Devang K.

AU - Sen, Ayan

AU - Siegel, Jason L.

AU - Singbartl, Kai

AU - Shah, Aditya S.

AU - Shweta, F. N.U.

AU - Speicher, Leigh L.

AU - Suh, Gina

AU - Tabaja, Hussam

AU - Tande, Aaron

AU - Ting, Henry H.

AU - Tontz, Russell C.

AU - Vaillant, James J.

AU - Vergidis, Paschalis

AU - Warsame, Mohamed Y.

AU - Yetmar, Zachary A.

AU - Zomok, Catherine (Cate) D.

AU - Williams, Amy W.

AU - Badley, Andrew D.

PY - 2021/3

Y1 - 2021/3

N2 - Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes. Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models. Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19–directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care. Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic.

AB - Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes. Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models. Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19–directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care. Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic.

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DO - 10.1016/j.mayocp.2020.12.006

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SN - 0025-6196

VL - 96

SP - 601

EP - 618

JO - Mayo Clinic proceedings

JF - Mayo Clinic proceedings

IS - 3

ER -

Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

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