Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery

Irene T. Ma, Richard J. Gray, Nabil Wasif, Kristina A. Butler, Jeffrey L Cornella, Javier F. Magrina, Paul M. Magtibay, William J. Casey, Raman Mahabir, Alanna M. Rebecca, Katherine S. Hunt, Barbara A Pockaj

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Women considering risk reduction surgery after a diagnosis of breast/ovarian cancer and/or inherited cancer gene mutation face difficult decisions. The safety of combined breast and gynecologic surgery has not been well studied; therefore, we evaluated the outcomes for patients who have undergone coordinated multispecialty surgery. Methods: We conducted a retrospective review of patients undergoing simultaneous breast and gynecologic surgery for newly or previously diagnosed breast cancer and/or an inherited cancer gene mutation during the same anesthetic at a single institution from 1999 to 2013. Results: Seventy-three patients with a mean age of 50 years (range 27–88) were identified. Most patients had newly diagnosed breast cancer or ductal carcinoma in situ (62 %) and 28 patients (38 %) had an identified BRCA mutation. Almost all gynecologic procedures were for risk reduction or benign gynecologic conditions (97 %). Mastectomy was performed in 39 patients (53 %), the majority of whom (79 %) underwent immediate reconstruction. The most common gynecologic procedure involved bilateral salpingo-oophorectomy, which was performed alone in 18 patients (25 %) and combined with hysterectomy in 40 patients (55 %). A total of 32 patients (44 %) developed postoperative complications, most of which were minor and did not require surgical intervention or hospitalization. Two of the 19 patients who underwent implant reconstruction (11 %; 3 % of the entire cohort) had major infectious complications requiring explantation. Conclusion: Combined breast and gynecologic procedures for a breast cancer diagnosis and/or risk reduction in patients can be accomplished with acceptable morbidity. Concurrent operations, including reconstruction, can be offered to patients without negatively impacting their outcome.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAnnals of Surgical Oncology
DOIs
StateAccepted/In press - Aug 31 2016

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Risk Reduction Behavior
Breast
Breast Neoplasms
Gynecologic Surgical Procedures
Neoplasm Genes
Mutation
Carcinoma, Intraductal, Noninfiltrating
Mastectomy
Ovariectomy
Hysterectomy
Ovarian Neoplasms
Anesthetics
Hospitalization
Morbidity
Safety

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery. / Ma, Irene T.; Gray, Richard J.; Wasif, Nabil; Butler, Kristina A.; Cornella, Jeffrey L; Magrina, Javier F.; Magtibay, Paul M.; Casey, William J.; Mahabir, Raman; Rebecca, Alanna M.; Hunt, Katherine S.; Pockaj, Barbara A.

In: Annals of Surgical Oncology, 31.08.2016, p. 1-7.

Research output: Contribution to journalArticle

Ma, IT, Gray, RJ, Wasif, N, Butler, KA, Cornella, JL, Magrina, JF, Magtibay, PM, Casey, WJ, Mahabir, R, Rebecca, AM, Hunt, KS & Pockaj, BA 2016, 'Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery', Annals of Surgical Oncology, pp. 1-7. https://doi.org/10.1245/s10434-016-5479-6
Ma, Irene T. ; Gray, Richard J. ; Wasif, Nabil ; Butler, Kristina A. ; Cornella, Jeffrey L ; Magrina, Javier F. ; Magtibay, Paul M. ; Casey, William J. ; Mahabir, Raman ; Rebecca, Alanna M. ; Hunt, Katherine S. ; Pockaj, Barbara A. / Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery. In: Annals of Surgical Oncology. 2016 ; pp. 1-7.
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abstract = "Background: Women considering risk reduction surgery after a diagnosis of breast/ovarian cancer and/or inherited cancer gene mutation face difficult decisions. The safety of combined breast and gynecologic surgery has not been well studied; therefore, we evaluated the outcomes for patients who have undergone coordinated multispecialty surgery. Methods: We conducted a retrospective review of patients undergoing simultaneous breast and gynecologic surgery for newly or previously diagnosed breast cancer and/or an inherited cancer gene mutation during the same anesthetic at a single institution from 1999 to 2013. Results: Seventy-three patients with a mean age of 50 years (range 27–88) were identified. Most patients had newly diagnosed breast cancer or ductal carcinoma in situ (62 {\%}) and 28 patients (38 {\%}) had an identified BRCA mutation. Almost all gynecologic procedures were for risk reduction or benign gynecologic conditions (97 {\%}). Mastectomy was performed in 39 patients (53 {\%}), the majority of whom (79 {\%}) underwent immediate reconstruction. The most common gynecologic procedure involved bilateral salpingo-oophorectomy, which was performed alone in 18 patients (25 {\%}) and combined with hysterectomy in 40 patients (55 {\%}). A total of 32 patients (44 {\%}) developed postoperative complications, most of which were minor and did not require surgical intervention or hospitalization. Two of the 19 patients who underwent implant reconstruction (11 {\%}; 3 {\%} of the entire cohort) had major infectious complications requiring explantation. Conclusion: Combined breast and gynecologic procedures for a breast cancer diagnosis and/or risk reduction in patients can be accomplished with acceptable morbidity. Concurrent operations, including reconstruction, can be offered to patients without negatively impacting their outcome.",
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AU - Gray, Richard J.

AU - Wasif, Nabil

AU - Butler, Kristina A.

AU - Cornella, Jeffrey L

AU - Magrina, Javier F.

AU - Magtibay, Paul M.

AU - Casey, William J.

AU - Mahabir, Raman

AU - Rebecca, Alanna M.

AU - Hunt, Katherine S.

AU - Pockaj, Barbara A

PY - 2016/8/31

Y1 - 2016/8/31

N2 - Background: Women considering risk reduction surgery after a diagnosis of breast/ovarian cancer and/or inherited cancer gene mutation face difficult decisions. The safety of combined breast and gynecologic surgery has not been well studied; therefore, we evaluated the outcomes for patients who have undergone coordinated multispecialty surgery. Methods: We conducted a retrospective review of patients undergoing simultaneous breast and gynecologic surgery for newly or previously diagnosed breast cancer and/or an inherited cancer gene mutation during the same anesthetic at a single institution from 1999 to 2013. Results: Seventy-three patients with a mean age of 50 years (range 27–88) were identified. Most patients had newly diagnosed breast cancer or ductal carcinoma in situ (62 %) and 28 patients (38 %) had an identified BRCA mutation. Almost all gynecologic procedures were for risk reduction or benign gynecologic conditions (97 %). Mastectomy was performed in 39 patients (53 %), the majority of whom (79 %) underwent immediate reconstruction. The most common gynecologic procedure involved bilateral salpingo-oophorectomy, which was performed alone in 18 patients (25 %) and combined with hysterectomy in 40 patients (55 %). A total of 32 patients (44 %) developed postoperative complications, most of which were minor and did not require surgical intervention or hospitalization. Two of the 19 patients who underwent implant reconstruction (11 %; 3 % of the entire cohort) had major infectious complications requiring explantation. Conclusion: Combined breast and gynecologic procedures for a breast cancer diagnosis and/or risk reduction in patients can be accomplished with acceptable morbidity. Concurrent operations, including reconstruction, can be offered to patients without negatively impacting their outcome.

AB - Background: Women considering risk reduction surgery after a diagnosis of breast/ovarian cancer and/or inherited cancer gene mutation face difficult decisions. The safety of combined breast and gynecologic surgery has not been well studied; therefore, we evaluated the outcomes for patients who have undergone coordinated multispecialty surgery. Methods: We conducted a retrospective review of patients undergoing simultaneous breast and gynecologic surgery for newly or previously diagnosed breast cancer and/or an inherited cancer gene mutation during the same anesthetic at a single institution from 1999 to 2013. Results: Seventy-three patients with a mean age of 50 years (range 27–88) were identified. Most patients had newly diagnosed breast cancer or ductal carcinoma in situ (62 %) and 28 patients (38 %) had an identified BRCA mutation. Almost all gynecologic procedures were for risk reduction or benign gynecologic conditions (97 %). Mastectomy was performed in 39 patients (53 %), the majority of whom (79 %) underwent immediate reconstruction. The most common gynecologic procedure involved bilateral salpingo-oophorectomy, which was performed alone in 18 patients (25 %) and combined with hysterectomy in 40 patients (55 %). A total of 32 patients (44 %) developed postoperative complications, most of which were minor and did not require surgical intervention or hospitalization. Two of the 19 patients who underwent implant reconstruction (11 %; 3 % of the entire cohort) had major infectious complications requiring explantation. Conclusion: Combined breast and gynecologic procedures for a breast cancer diagnosis and/or risk reduction in patients can be accomplished with acceptable morbidity. Concurrent operations, including reconstruction, can be offered to patients without negatively impacting their outcome.

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