Outcomes Following Three-Factor Inactive Prothrombin Complex Concentrate Versus Recombinant Activated Factor VII Administration During Cardiac Surgery

Patrick C. Harper, Mark M. Smith, Nathan J. Brinkman, Melissa A. Passe, Darrell R. Schroeder, Sameh M. Said, Gregory A. Nuttall, William C. Oliver, David W. Barbara

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: To compare outcomes following inactive prothrombin complex concentrate (PCC) or recombinant activated factor VII (rFVIIa) administration during cardiac surgery. Design: Retrospective propensity-matched analysis. Setting: Academic tertiary-care center. Participants: Patients undergoing cardiac surgery requiring cardiopulmonary bypass who received either rFVIIa or the inactive 3-factor PCC. Interventions: Outcomes following intraoperative administration of rFVIIa (263) or factor IX complex (72) as rescue therapy to treat bleeding. Measurements and Main Results: In the 24 hours after surgery, propensity-matched patients receiving PCC versus rFVIIa had significantly less chest tube outputs (median difference –464 mL, 95% confidence interval [CI] –819 mL to –110 mL), fresh frozen plasma transfusion rates (17% v 38%, p = 0.028), and platelet transfusion rates (26% v 49%, p = 0.027). There were no significant differences between propensity-matched groups in postoperative stroke, deep venous thrombosis, pulmonary embolism, myocardial infarction, or intracardiac thrombus. Postoperative dialysis was significantly less likely in patients administered PCC versus rFVIIa following propensity matching (odds ratio = 0.3, 95% CI 0.1-0.7). No significant difference in 30-day mortality in patients receiving PCC versus rFVIIa was present following propensity matching. Conclusions: Use of rFVIIa versus inactive PCCs was significantly associated with renal failure requiring dialysis and increased postoperative bleeding and transfusions.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume32
Issue number1
DOIs
StatePublished - Feb 2018

Keywords

  • Bebulin
  • NovoSeven
  • cardiac surgery
  • factor IX complex
  • prothrombin complex concentrate
  • recombinant activated factor VII

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Outcomes Following Three-Factor Inactive Prothrombin Complex Concentrate Versus Recombinant Activated Factor VII Administration During Cardiac Surgery'. Together they form a unique fingerprint.

Cite this