Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer Patients

Brittany L. Murphy, Tanya L. Hoskin, Judy C. Boughey, Amy C. Degnim, James W. Jakub, Adam C. Krajewski, Steven R. Jacobson, Tina J. Hieken

Research output: Contribution to journalComment/debatepeer-review

7 Scopus citations

Abstract

Background While nipple-sparing mastectomy (NSM) is gaining acceptance for risk reduction and for treatment of early stage breast cancer, node-positive disease remains a relative contraindication. Our aim was to evaluate the use and outcomes of NSM in node-positive breast cancer patients. Methods We identified 240 cancers in 226 patients (14 bilateral) scheduled for NSM and operated on between 1/2009 and 6/2014. We compared outcomes for 58 node-positive vs 182 node-negative patients. Results Intraoperative conversion to skin-sparing mastectomy was similar for node-positive and node-negative patients, 10% and 7%, as was 1-year success of NSM, 84% and 90%, respectively. Five-year locoregional disease-free estimates were 82% (95% CI 68%–99%) for node-positive and 99% (95% CI 96%–100%) for node-negative patients, P = .004; however, there were no nipple-areolar recurrences among node-positive patients. Conclusions With careful consideration of biologic and anatomic risk factors for recurrence, these data suggest that NSM is a reasonable option for selected node-positive breast cancer patients.

Original languageEnglish (US)
Pages (from-to)810-813
Number of pages4
JournalAmerican journal of surgery
Volume213
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Breast cancer
  • Local recurrence
  • Lymph node
  • Nipple-sparing mastectomy
  • Node-positive
  • Outcomes

ASJC Scopus subject areas

  • Surgery

Fingerprint

Dive into the research topics of 'Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer Patients'. Together they form a unique fingerprint.

Cite this