Abstract
Background/Aim: Reconstruction for soft-tissue sarcomas is complex and often uses soft-tissue flaps. To preserve critical structures, intraoperative radiotherapy (IORT) can be used to boost the total dose to these critical structures and close margins; however, there are limited data on the outcome of soft-tissue reconstruction in patients treated with IORT. Patients and Methods: Twenty patients received IORT with soft-tissue flap coverage. There were 14 tumors of the lower extremities and six of the upper, including seven free-flaps and 13 pedicle flaps. Mean preoperative and IORT doses were 49.4 Gy and 10.4 Gy, respectively, with a mean total dose of 59.8 Gy. Results: Seven (35%) patients had a complication, most commonly an infection (n=4, 27%). Total flap loss occurred in one treated with pedicle flap. Four (20%) patients suffered a radiation-associated fracture. At the final follow-up, the mean Musculoskeletal Tumor Society Score was 75±11%. Conclusion: Complications and postoperative fractures were common with IORT, however, there were no cases requiring amputation.
Original language | English (US) |
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Pages (from-to) | 6941-6945 |
Number of pages | 5 |
Journal | Anticancer research |
Volume | 40 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- Flap
- IORT
- Intraoperative radiotherapy
- Limb salvage
- Soft-tissue reconstruction
ASJC Scopus subject areas
- Oncology
- Cancer Research