TY - JOUR
T1 - Outcome of Myelodysplastic Syndromes Over Time in the United States
T2 - A National Cancer Data Base Study From 2004-2013
AU - Al-Kali, Aref
AU - Zblewski, D.
AU - Foran, James M.
AU - Patnaik, Mrinal S.
AU - Larrabee, Beth R.
AU - Gangat, Naseema
AU - Begna, Kebede H.
AU - Elliott, Michelle A.
AU - Hogan, William J.
AU - Tefferi, Ayalew
AU - Litzow, Mark R.
AU - Go, Ronald S.
N1 - Publisher Copyright:
© 2019 Mayo Foundation for Medical Education and Research
PY - 2019/8
Y1 - 2019/8
N2 - Objective: To study the changes in overall outcome of patients with myelodysplastic syndromes (MDSs) after approval of several treatments. Patients and Methods: We identified 54,953 MDS cases in the National Cancer Data Base diagnosed from January 1, 2004, through December 31, 2013, using International Classification of Diseases for Oncology, 3rd edition, codes 9980, 9982-9983, 9985-9987, 9989, 9991-9992. Overall survival and different subgroups were studied over 3 periods of diagnoses (2004-2006, 2007-2009, and 2010-2013). Results: Median age at diagnosis was 76 years. The most common subtype was MDS-unclassifiable, which represented 55.6% of all cases. We found that males, older patients, patients with refractory anemia with excess blasts, Medicare insurance recipients, and those treated at nonacademic centers had the worse survival (P<.001). Overall survival did not improve over time, except in younger patients (<40 years old). Conclusion: In the past decade, overall outcome of MDS did not improve despite the advent of new therapies. More studies are needed to understand the impact of newly approved treatments on the outcome of patients with MDS.
AB - Objective: To study the changes in overall outcome of patients with myelodysplastic syndromes (MDSs) after approval of several treatments. Patients and Methods: We identified 54,953 MDS cases in the National Cancer Data Base diagnosed from January 1, 2004, through December 31, 2013, using International Classification of Diseases for Oncology, 3rd edition, codes 9980, 9982-9983, 9985-9987, 9989, 9991-9992. Overall survival and different subgroups were studied over 3 periods of diagnoses (2004-2006, 2007-2009, and 2010-2013). Results: Median age at diagnosis was 76 years. The most common subtype was MDS-unclassifiable, which represented 55.6% of all cases. We found that males, older patients, patients with refractory anemia with excess blasts, Medicare insurance recipients, and those treated at nonacademic centers had the worse survival (P<.001). Overall survival did not improve over time, except in younger patients (<40 years old). Conclusion: In the past decade, overall outcome of MDS did not improve despite the advent of new therapies. More studies are needed to understand the impact of newly approved treatments on the outcome of patients with MDS.
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U2 - 10.1016/j.mayocp.2019.02.029
DO - 10.1016/j.mayocp.2019.02.029
M3 - Article
C2 - 31378228
AN - SCOPUS:85069881096
SN - 0025-6196
VL - 94
SP - 1467
EP - 1474
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 8
ER -