Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy

Ricky W. Lee, Marietta M. Hoogs, David B. Burkholder, Max R. Trenerry, Joseph F. Drazkowski, Jerry J. Shih, Karey E. Doll, William O. Tatum, Gregory D. Cascino, W. Richard Marsh, Elaine C. Wirrell, Gregory A. Worrell, Elson L. So

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We evaluated the outcomes of intracranial electroencephalography (iEEG) recording and subsequent resective surgery in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE). Thirty-two patients were identified from the Mayo Clinic Epilepsy Surgery Database (Arizona, Florida, and Minnesota). Eight (25.0%) had chronic iEEG monitoring that recorded neocortical temporal seizure onsets; 12 (37.5%) had mesial temporal seizure onsets; 5 (15.6%) had independent neocortical and mesial temporal seizure onsets; and 7 (21.9%) had simultaneous neocortical and mesial seizure onsets. Neocortical temporal lobe seizure semiology was the only factor significantly associated with neocortical temporal seizure onsets on iEEG. Only 33.3% of patients who underwent lateral temporal neocorticectomy had an Engel class 1 outcome, whereas 76.5% of patients with iEEG-guided anterior temporal lobectomy that included the amygdala and the hippocampus had an Engel class 1 outcome. Limitations in cohort size precluded statistical analysis of neuropsychological test data.

Original languageEnglish (US)
Pages (from-to)937-944
Number of pages8
JournalEpilepsy Research
Volume108
Issue number5
DOIs
StatePublished - Jul 2014

Keywords

  • Epilepsy surgery
  • Intracranial electroencephalography
  • Normal magnetic resonance imaging
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Lee, R. W., Hoogs, M. M., Burkholder, D. B., Trenerry, M. R., Drazkowski, J. F., Shih, J. J., Doll, K. E., Tatum, W. O., Cascino, G. D., Marsh, W. R., Wirrell, E. C., Worrell, G. A., & So, E. L. (2014). Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy. Epilepsy Research, 108(5), 937-944. https://doi.org/10.1016/j.eplepsyres.2014.03.013