Outcome of critically ill patients with influenza virus infection

Guangxi Li, Murat Yilmaz, Marija Kojicic, Evans Fernández-Pérez, Raed Wahab, W Charles Huskins, Bekele Afessa, Jonathon D. Truwit, Ognjen Gajic

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Influenza is a major cause of morbidity and mortality, with its greatest burden on the elderly and patients with chronic co-morbidities in the intensive care unit (ICU). An accurate prognosis is essential for decision-making during pandemic as well as interpandemic periods. Methods: A retrospective cohort study was conducted to determine prognostic factors influencing short term outcome of critically ill patients with confirmed influenza virus infection. Baseline characteristics, laboratory and diagnostic findings, ICU interventions and complications were abstracted from medical records using standard definitions and compared between hospital survivors and non-survivors with univariate and multivariate logistic regression analyses. Results: 111 patients met the inclusion criteria. Acute respiratory distress syndrome (ARDS) complicated ICU course in 25 (23%) of the patients, with mortality rate of 52%. Multivariate logistic regression analysis identified the following predictors of hospital mortality: Acute Physiology and Chronic Health Evaluation (APACHE) III predicted mortality (Odds ratio [OR] 1.49, 95% confidence interval [CI] 1.1-2.1 for 10% increase), ARDS (OR 7.7, 95% CI 2.3-29) and history of immunosuppression (OR 7.19, 95% CI 1.9-28). Conclusions: APACHE III predicted mortality, the development of ARDS and the history of immunosuppression are independent risk factors for hospital mortality in critically ill patients with confirmed influenza virus infection.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalJournal of Clinical Virology
Volume46
Issue number3
DOIs
StatePublished - Nov 2009

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Virus Diseases
Orthomyxoviridae
Critical Illness
Adult Respiratory Distress Syndrome
Intensive Care Units
APACHE
Mortality
Odds Ratio
Confidence Intervals
Hospital Mortality
Immunosuppression
Logistic Models
Regression Analysis
Morbidity
Pandemics
Human Influenza
Medical Records
Survivors
Decision Making
Cohort Studies

Keywords

  • Human
  • ICUs
  • Influenza
  • Outcome Assessment
  • Prognosis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Outcome of critically ill patients with influenza virus infection. / Li, Guangxi; Yilmaz, Murat; Kojicic, Marija; Fernández-Pérez, Evans; Wahab, Raed; Huskins, W Charles; Afessa, Bekele; Truwit, Jonathon D.; Gajic, Ognjen.

In: Journal of Clinical Virology, Vol. 46, No. 3, 11.2009, p. 275-278.

Research output: Contribution to journalArticle

Li, G, Yilmaz, M, Kojicic, M, Fernández-Pérez, E, Wahab, R, Huskins, WC, Afessa, B, Truwit, JD & Gajic, O 2009, 'Outcome of critically ill patients with influenza virus infection', Journal of Clinical Virology, vol. 46, no. 3, pp. 275-278. https://doi.org/10.1016/j.jcv.2009.07.015
Li, Guangxi ; Yilmaz, Murat ; Kojicic, Marija ; Fernández-Pérez, Evans ; Wahab, Raed ; Huskins, W Charles ; Afessa, Bekele ; Truwit, Jonathon D. ; Gajic, Ognjen. / Outcome of critically ill patients with influenza virus infection. In: Journal of Clinical Virology. 2009 ; Vol. 46, No. 3. pp. 275-278.
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