Outcome disparities among ethnic subgroups of waldenström's macroglobulinemia: A population-based study

Sikander Ailawadhi, Adel Kardosh, Dongyun Yang, Wendy Cozen, Gaurav Patel, Mohammad A. Alamgir, Asher A. Chanan-Khan

Research output: Contribution to journalArticle

12 Scopus citations


Background: Ethnic disparities in cancers are associated with variability in clinical outcomes. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of multiethnic Waldenström's macroglobulinemia (WM) patients. Methods: Adult WM patients diagnosed in 1992 or later (n = 3,175) were analyzed. Median overall survival (OS) was compared across different ethnicities stratified by year of diagnosis, registry identification, age at diagnosis, sex, and marital status. Results: African-Americans (AA) had the youngest median age at diagnosis (63 years) and Whites had the oldest (73 years) (p < 0.001). Female gender, a younger age at diagnosis, and a recent year of diagnosis were associated with an improved OS. Hispanics had the worst (5.6 years) while Whites had the best (6.8 years) median OS. A significant interaction existed between median OS, gender, and race (p = 0.007). Among males, AA had the worst (4.3 years) and Asians had the best (7.3 years) median OS. A significant interaction was also noted between median OS, age at diagnosis, and race (p = 0.033). The worst median OS was seen in Hispanics among patients aged >75 years, and in AA among those aged <65 years. Conclusions: These disparities among WM patients may be multifactorial but need to be explored systematically to better understand the disease biology and for optimal triaging of health care resources.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalOncology (Switzerland)
Issue number5-6
StatePublished - Jul 2014



  • Disparity
  • Ethnicity
  • Surveillance Epidemiology and End Results
  • Survival
  • Waldenström's macroglobulinemia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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